The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk.
The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk.
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DOI：
10.1007/s10549-013-2646-3
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发表时间：
2013-07
影响因子：
3.8
通讯作者：
Newcomb, Polly A.
中科院分区：
文献类型：
--
作者：
Andersen, Shaneda Warren;Trentham-Dietz, Amy;Gangnon, Ronald E.;Hampton, John M.;Figueroa, Jonine D.;Skinner, Halcyon G.;Engelman, Corinne D.;Klein, Barbara E.;Titus, Linda J.;Newcomb, Polly A.
我们评估了全基因组关联研究中确定的13个单核苷酸多态性（SNP）是否相互作用，以及与乳腺癌风险相关的生殖和月经风险因素。DNA样本和信息的奇偶校验，母乳喂养，初潮年龄，第一次生育年龄，绝经年龄，通过结构化访谈收集了1484例乳腺癌病例和1307例对照，他们参加了在美国三个州进行的以人群为基础的病例对照研究。多基因得分被创建为风险等位基因拷贝的总和乘以相应的对数比值估计。Logistic回归分析用于检验SNPs、评分、生殖和月经因素与乳腺癌风险之间的关联。通过纳入多基因评分的二次项来评估评分的非线性。上述变量之间的相互作用进行了测试，包括在模型中的交叉产品项。我们证实了rs 13387042（2 q35）、rs 4973768（SLC 4A 7）、rs 10941679（5 p12）、rs 2981582（FGFR 2）、rs3817198（LSP 1）、rs3803662（TOX 3）和rs6504950（STXBP 4）与乳腺癌的相关性。得分最高的五分之一的妇女与得分最低的五分之一的妇女相比，风险增加了2.2倍（95%置信区间：1.67-2.88）。二次多基因评分项在模型中不显著（p=0.85），表明已建立的乳腺癌基因座与风险增加的相关性不超过风险等位基因的总和。月经和生殖风险因素与乳腺癌风险的多基因评分的修改没有观察到。我们的研究结果表明，乳腺癌易感基因座和生殖因素之间的相互作用并不是乳腺癌风险的重要因素。
We evaluated whether 13 single nucleotide polymorphisms (SNPs) identified in genome-wide association studies interact with one another and with reproductive and menstrual risk factors in association with breast cancer risk. DNA samples and information on parity, breastfeeding, age at menarche, age at first birth, and age at menopause were collected through structured interviews from 1484 breast cancer cases and 1307 controls who participated in a population-based case-control study conducted in three U.S. states. A polygenic score was created as the sum of risk allele copies multiplied by the corresponding log odds estimate. Logistic regression was used to test associations between SNPs, the score, reproductive and menstrual factors and breast cancer risk. Nonlinearity of the score was assessed by the inclusion of a quadratic term for polygenic score. Interactions between the aforementioned variables were tested by including a cross-product term in models. We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3) and rs6504950 (STXBP4) with breast cancer. Women in the score’s highest quintile had 2.2-fold increased risk when compared to women in the lowest quintile (95% confidence interval:1.67–2.88). The quadratic polygenic score term was not significant in the model (p=0.85), suggesting established breast cancer loci are not associated with increased risk more than the sum of risk alleles. Modifications of menstrual and reproductive risk factors associations with breast cancer risk by polygenic score were not observed. Our results suggest interactions between breast cancer susceptibility loci and reproductive factors are not strong contributors to breast cancer risk.
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DOI：
10.1158/1055-9965.epi-10-0054
发表时间：
2010-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Long J;Shu XO;Cai Q;Gao YT;Zheng Y;Li G;Li C;Gu K;Wen W;Xiang YB;Lu W;Zheng W
通讯作者：
Zheng W
DOI：
10.1093/jnci/djq388
发表时间：
2010-11-03
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Mealiffe ME;Stokowski RP;Rhees BK;Prentice RL;Pettinger M;Hinds DA
通讯作者：
Hinds DA
影响因子：
30.8
作者：
Zheng, Wei;Long, Jirong;Gao, Yu-Tang;Li, Chun;Zheng, Ying;Xiang, Yong-Bin;Wen, Wanqing;Levy, Shawn;Deming, Sandra L.;Haines, Jonathan L.;Gu, Kai;Fair, Alecia Malin;Cai, Qiuyin;Lu, Wei;Shu, Xiao-Ou
通讯作者：
Shu, Xiao-Ou
影响因子：
4.7
作者：
Rebbeck, Timothy R.;DeMichele, Angela;Strom, Brian L.
通讯作者：
Strom, Brian L.
DOI：
10.1186/bcr2797
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Milne RL;Gaudet MM;Spurdle AB;Fasching PA;Couch FJ;Benítez J;Arias Pérez JI;Zamora MP;Malats N;Dos Santos Silva I;Gibson LJ;Fletcher O;Johnson N;Anton-Culver H;Ziogas A;Figueroa J;Brinton L;Sherman ME;Lissowska J;Hopper JL;Dite GS;Apicella C;Southey MC;Sigurdson AJ;Linet MS;Schonfeld SJ;Freedman DM;Mannermaa A;Kosma VM;Kataja V;Auvinen P;Andrulis IL;Glendon G;Knight JA;Weerasooriya N;Cox A;Reed MW;Cross SS;Dunning AM;Ahmed S;Shah M;Brauch H;Ko YD;Brüning T;GENICA Network;Lambrechts D;Reumers J;Smeets A;Wang-Gohrke S;Hall P;Czene K;Liu J;Irwanto AK;Chenevix-Trench G;Holland H;kConFab;AOCS;Giles GG;Baglietto L;Severi G;Bojensen SE;Nordestgaard BG;Flyger H;John EM;West DW;Whittemore AS;Vachon C;Olson JE;Fredericksen Z;Kosel M;Hein R;Vrieling A;Flesch-Janys D;Heinz J;Beckmann MW;Heusinger K;Ekici AB;Haeberle L;Humphreys MK;Morrison J;Easton DF;Pharoah PD;García-Closas M;Goode EL;Chang-Claude J
通讯作者：
Chang-Claude J