Maternal Gestational Diabetes Is Associated With Offspring's Hypertension
Maternal Gestational Diabetes Is Associated With Offspring's Hypertension
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DOI：
10.1093/ajh/hpz005
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发表时间：
2019-04-01
影响因子：
3.2
通讯作者：
Hu, Gang
中科院分区：
文献类型：
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作者：
Lu, Jun;Zhang, Shuang;Hu, Gang
目的多项研究评估母亲妊娠期糖尿病（GDM）与儿童期高血压的风险，结果不一致。我们调查了母亲GDM和子女在幼儿期高血压风险之间的关系。方法我们在1,156对母亲-子女中进行了一项大型研究（578 GDM和578 non-GDM匹配其子女的年龄和性别）。根据世界卫生组织标准诊断GDM。使用标准化方法测量儿童身高、体重和血压。年龄、性别、身高特异性血压Z评分、儿童期高血压、高血压按照全国高血压教育项目儿童青少年高血压工作组参考范围进行评估。妊娠期GDM母亲所生的儿童收缩压Z评分平均值较高与妊娠期非GDM母亲所生的对照组相比，GDM母亲所生的妊娠期非GDM妇女的高血压患病率（6.4%对3.5%）和高血压患病率（15.6%对9.3%）更高（均P值
OBJECTIVE Several studies assessed maternal gestational diabetes mellitus (GDM) with the risk of childhood high blood pressure, and the results were inconsistent. We investigated the association between maternal GDM and hypertension risk in offspring during early childhood.METHODS We performed a large study in 1,156 mother-child pairs (578 GDM and 578 non-GDM matched by their offspring's age and sex). Maternal GDM was diagnosed according to the World Health Organization criteria. Childhood height, weight, and blood pressure were measured using standardized methods. Age-, sex-, and height-specific blood pressure Z score, childhood hypertension, and high blood pressure were evaluated according to the reference range of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents.RESULTS After adjustment for maternal and children's characteristics, children born to mothers with GDM during pregnancy had higher mean values of systolic blood pressure Z score (0.09 vs. -0.17), and higher prevalence of hypertension (6.4% vs. 3.5%) and high blood pressure (15.6% vs. 9.3%) in comparison with their counterparts born to mothers without GDM during pregnancy (all P values