Asymmetric right/left encoding of emotions in the human subthalamic nucleus.
Asymmetric right/left encoding of emotions in the human subthalamic nucleus.
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DOI：
10.3389/fnsys.2013.00069
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发表时间：
2013
影响因子：
3
通讯作者：
Israel Z
中科院分区：
文献类型：
--
作者：
Eitan R;Shamir RR;Linetsky E;Rosenbluh O;Moshel S;Ben-Hur T;Bergman H;Israel Z
情绪处理被偏向于非支配的大脑半球。然而，基底节中情绪域的偏侧化还没有明确的空间模型。丘脑底核(STN)是基底节网络的输入结构，在帕金森病(PD)的病理生理学中起着重要作用。这一作用可能不仅限于帕金森病患者的运动障碍，还可能跨越帕金森病患者常见的情感和认知障碍。β振荡(12-30赫兹)是帕金森病的电生理特征，局限于STN的背外侧部分，对应于解剖学上定义的感觉运动STN。STN的更内侧、更前方和更腹侧的部分被认为与解剖上定义的STN的边缘和联合区域相对应。令人惊讶的是，人们对STN的非运动区的电生理特性知之甚少，也不知道左右sTN之间的电生理差异。本研究利用微电极记录帕金森病患者脑深部刺激(DBS)手术中STN的自发放电活动和对发声非言语情绪刺激的反应。利用STN神经元的振荡特性来定位STN的背侧振荡区和腹侧非振荡区。情绪听觉刺激引起右侧STN腹侧非振荡区的活动。这些反应在左侧腹侧STN或右侧或左侧STN背侧区域均未观察到。因此，我们的结果表明，腹侧非振荡区与非运动功能是不对称的，而右腹侧STN与情绪处理有关。这些结果表明，右侧腹侧STN的DBS可能与PD患者观察到的有利或不利的情绪影响有关，并可能缓解其他神经和精神疾病的精神症状。
Emotional processing is lateralized to the non-dominant brain hemisphere. However, there is no clear spatial model for lateralization of emotional domains in the basal ganglia. The subthalamic nucleus (STN), an input structure in the basal ganglia network, plays a major role in the pathophysiology of Parkinson's disease (PD). This role is probably not limited only to the motor deficits of PD, but may also span the emotional and cognitive deficits commonly observed in PD patients. Beta oscillations (12–30 Hz), the electrophysiological signature of PD, are restricted to the dorsolateral part of the STN that corresponds to the anatomically defined sensorimotor STN. The more medial, more anterior and more ventral parts of the STN are thought to correspond to the anatomically defined limbic and associative territories of the STN. Surprisingly, little is known about the electrophysiological properties of the non-motor domains of the STN, nor about electrophysiological differences between right and left STNs. In this study, microelectrodes were utilized to record the STN spontaneous spiking activity and responses to vocal non-verbal emotional stimuli during deep brain stimulation (DBS) surgeries in human PD patients. The oscillation properties of the STN neurons were used to map the dorsal oscillatory and the ventral non-oscillatory regions of the STN. Emotive auditory stimulation evoked activity in the ventral non-oscillatory region of the right STN. These responses were not observed in the left ventral STN or in the dorsal regions of either the right or left STN. Therefore, our results suggest that the ventral non-oscillatory regions are asymmetrically associated with non-motor functions, with the right ventral STN associated with emotional processing. These results suggest that DBS of the right ventral STN may be associated with beneficial or adverse emotional effects observed in PD patients and may relieve mental symptoms in other neurological and psychiatric diseases.