Anthrax as a biological weapon - Medical and public health management
Anthrax as a biological weapon - Medical and public health management
复制标题
DOI：
10.1001/jama.281.18.1735
复制
发表时间：
1999-05-12
影响因子：
120.7
通讯作者：
Tonat, K
中科院分区：
文献类型：
--
作者：
Inglesby, TV;Henderson, DA;Tonat, K
目的就医疗和公共卫生专业人员在使用炭疽作为针对平民的生物武器后应采取的措施提出基于共识的建议。工作组的参与者包括来自主要学术医疗中心和研究机构、政府、军队、公共卫生和应急管理机构和机构的21名代表。证据检索自1966年1月至1998年4月的MEDLINE数据库，检索的医学主题为炭疽、炭疽芽孢杆菌、生物武器、生物恐怖主义、生物战和生物战。通过对参考文献的回顾，确定了1966年之前发表的相关参考文献，此外，参与者还确定了其他未发表的参考文献和来源。共识声明的初稿综合了在正式证据收集过程中获得的信息。工作组成员提供了正式的书面评论，这些评论已纳入声明第二稿。工作组于1998年6月12日审议了第二稿。没有重大分歧，意见被纳入第三稿。第四项也是最后一项声明包含了通过文献检索获得的所有相关证据，以及所有工作组成员支持的最终共识建议。结论针对炭疽的诊断、疫苗接种指征、接触者的治疗、接触后预防、环境净化和其他研究需求提出了具体的共识建议。
Objective To develop consensus-based recommendations for measures to be taken by medical and public health professionals following the use of anthrax as a biological weapon against a civilian population.Participants The working group included 21 representatives from staff of major academic medical centers and research, government, military, public health, and emergency management institutions and agencies.Evidence MEDLINE databases were searched from January 1966 to April 1998, using the Medical Subject Headings anthrax, Bacillus anthracis, biological weapon, biological terrorism, biological warfare, and biowarfare. Review of references identified by this search led to identification of relevant references published prior to 1966, In addition, participants identified other unpublished references and sources.Consensus Process The first draft of the consensus statement was a synthesis of information obtained in the formal evidence-gathering process. Members of the working group provided formal written comments which were incorporated into the second draft of the statement. The working group reviewed the second draft on June 12, 1998. No significant disagreements existed and comments were incorporated into a third draft. The fourth and final statement incorporates all relevant evidence obtained by the literature search in conjunction with final consensus recommendations supported by all working group members.Conclusions Specific consensus recommendations are made regarding the diagnosis of anthrax, indications for vaccination, therapy for those exposed, postexposure prophylaxis, decontamination of the environment, and additional research needs.