Tellurium-123m-labeled-9-telluraheptadecanoic acid: a possible cardiac imaging agent.
Tellurium-123m-labeled-9-telluraheptadecanoic acid: a possible cardiac imaging agent.
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碲 123m 标记的 9-碲十七酸：一种可能的心脏显像剂。
DOI：
10.1161/01.cir.65.2.305
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发表时间：
1982
期刊：
影响因子：
37.8
通讯作者：
Strauss,HW
中科院分区：
文献类型：
--
作者：
Okada,RD;KnappJr,FF;Elmaleh,DR;Yasuda,T;Boucher,CA;Strauss,HW
为了研究脂肪酸类似物碲-123 m标记的-9-碲十七烷酸（123 mTe-THDA）作为心脏成像剂的价值，五只狗的左前降支冠状动脉部分闭塞。1小时后，将钪-46（Sc）微球注入左心房，随后立即静脉注射121 mTe-THDA。注射后，用微型碲化镉放射探测器连续监测缺血区和非缺血区心肌2 'SmTe活性。4小时后，左心房注射113锡微球，处死犬。将心肌缺血区和非缺血区切片，在孔计数器中计数。非缺血心肌123 mTe活性在注射后1分钟内达到峰值活性的88 ± 10%（平均± SD），在8 ± 9分钟达到峰值，然后在接下来的4小时内下降2 ± 8%。缺血心肌123 mTe活性在注射后1分钟内达到峰值的97.4%，在5 ~ 5 min达到峰值，然后在接下来的4小时内下降5.7%。1小时和4小时的121 mTe活度与OSc微球测定的心肌局部血流量呈线性相关（r= 0.93-0.96）。缺血区和非缺血区心肌血流量在实验过程中没有显着变化。在另外三只左前降支闭塞的狗和另外两只无闭塞的狗中，使用传统的γ闪烁照相机和低能量准直器，在123 mTe-THDA给药后获得了良好质量的心脏图像。
To study the value of the fatty acid analog tellurium-123m-labeled-9-telluraheptadecanoic acid (123mTe-THDA) as a cardiac imaging agent, five dogs had partial occlusion of the left anterior descending cor-onary artery. One hour later, scandium-46 (" Sc) microspheres were injected into the left atrium, followed immediately by the iv 121mTe-THDA. After injection, regional myocardial 2'SmTe activity was monitored con-tinuously with implanted miniature cadmium telluride radiation detectors in both ischemic and nonischemic zones. After 4 hours, stannum-113 microspheres were injected into the left atrium and the dogs were killed. Ischemic and nonischemic areas of myocardium were sectioned and counted in a well counter. Nonischemic myocardial 123mTe activity reached 88 ą 10%(mean ą SD) of peak activity within 1 minute after injection, peaked in 8 ą 9 minutes, then decreased 2 ą 8% over the next 4 hours. Ischemic myocardial 123mTe activity reached 97 ą 4% of peak activity within 1 minute after injection, peaked in 5 ą 5 minutes, then decreased 5 ą 7% over the next 4 hours. There was a linear correlation between 121mTe activity at 1 hour and at 4 hours and the initial" OSc microsphere-determined regional myocardial blood flow (r= 0.93-0.96). Ischemic and nonischemic zone myocardial blood flows did not change significantly during the experiment. Cardiac im-ages of excellent quality were obtained after 123mTe-THDA administration in three additional dogs with left anterior descending occlusions and two additional dogs with no occlusions using a conventional gamma scintillation camera and a low-energy collimator.