A genetic animal model of alcohol withdrawal
A genetic animal model of alcohol withdrawal
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DOI：
10.1111/j.1530-0277.1996.tb01754.x
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发表时间：
1996-11-01
影响因子：
3.2
通讯作者：
Crabbe, JC
中科院分区：
文献类型：
--
作者：
Crabbe, JC
在酒精研究中，使用遗传动物模型的工作有着悠久的历史。这里没有试图承认该地区许多其他长期项目的贡献。相反，我试图给出一个这样的项目的概括观点，并指出未来方向的一些领域。很明显，在不久的将来，分子生物学工具的表达将大大扩展我们的能力。这个领域很适合利用这种情况，因为它在“黑暗时代”取得了很大进展，当时对遗传影响的研究是推断性的：也就是说，我们仅限于研究我们无法识别的基因。未来肯定会引导我们识别和研究特定的重要基因。
Work with genetic animal models has a long history in alcohol research. No attempt has been made here to acknowledge the contributions of the many other long-standing projects in the area. Rather, I have tried to give a capsule view of one such project, and to indicate some areas of future direction. It seems clear that the expression of molecular biological tools will greatly expand our capabilities in the immediate future. The field is well-situated to take advantage of this situation, as it has achieved much progress during the" dark ages," where the study of genetic influence was inferential: that is, we were limited to studying genes we could not identify. The future will surely lead us to the identification and study of specific genes of importance.