Cerebellar connections to the dorsomedial and posterior nuclei of the hypothalamus in the rat
Cerebellar connections to the dorsomedial and posterior nuclei of the hypothalamus in the rat
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DOI：
10.1046/j.1469-7580.2001.19810037.x
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发表时间：
2001-01-01
影响因子：
2.4
通讯作者：
Onat, F
中科院分区：
文献类型：
--
作者：
Çavdar, S;San, T;Onat, F
小脑结构的刺激或消融产生了多种内脏反应，表明小脑在内脏功能中的作用。使用顺行和逆行追踪方法的研究揭示了下丘脑和小脑结构之间的联系。本研究的目的是利用辣根过氧化物酶 (HRP) 的逆行轴突运输来研究背内侧 (DMH) 和下丘脑后核的小脑连接。在本研究中，限制在 DMH 边界内的 HRP 显微注射表明，该核的投影在其整个范围内并不均匀。后 DMH 接收来自小脑的投射，而前 DMH 则不接收。这些投影来自（最大到最小浓度）外侧（齿状）、前插入（栓状）和内侧（顶）小脑核。此外，前部和后部 DMH 都接收来自脑干各个区域的投影，这证实了早期的研究并提供了详细的描述。这项研究还证明了将 HRP 注射到下丘脑后核后，标记的神经元在小脑和脑干核中的分布。它为小脑核-DMH 后核和小脑核-下丘脑后核的直接连接提供了明确的证据。我们认为，DMH 和下丘脑后部的脑干网状核和其他连接，例如孤立核、三叉神经核和前庭核，可能有助于间接小脑下丘脑连接。这些观察结果为小脑如何影响自主活动的问题提供了新的视角。
The stimulation or ablation of cerebellar structures has produced a variety of visceral responses, indicating a cerebellar role in visceral functions. Studies using anterograde and retrograde tracing methods have revealed connections between the hypothalamus and cerebellar structures. The aim of this study is to investigate the cerebellar connections of the dorsomedial (DMH) and posterior hypothalamic nuclei using retrograde axonal transport of horseradish peroxidase (HRP). In the present study, micro-injection of HRP restricted within the borders of the DMH showed that the projections of this nucleus are not uniform throughout its extent. The posterior DMH receives projections from the cerebellum whereas the anterior DMH does not. These projections were from the (greatest to least concentration) lateral (dentate), anterior interposed (emboliform), and medial (fastigial) cerebellar nuclei. In addition, both the anterior and posterior DMH receive projections from various areas of the brainstem which confirms earlier studies and provides detailed descriptions. This study also demonstrates the distribution of labelled neurons to cerebellar and brainstem nuclei following HRP injection into the posterior hypothalamic nucleus. It provides clear evidence for a direct cerebellar nuclei-posterior DMH and cerebellar nuclei-posterior hypothalamic nucleus connections. We suggest that the brainstem reticular nuclei and other connections, such as the solitary, trigeminal and vestibular nuclei, of both DMH and posterior hypothalamus may contribute to the indirect cerebellohypothalamic connections. These observations offer a new perspective on the question of how the cerebellum may influence autonomic activity.