DNA origami: The bridge from bottom to top
DNA origami: The bridge from bottom to top
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DOI：
10.1557/mrs.2017.275
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发表时间：
2017-12
期刊：
影响因子：
5
通讯作者：
Anqin Xu;J. Harb;M. Kostiainen;W. Hughes;A. Woolley;Haitao Liu;A. Gopinath
中科院分区：
文献类型：
--
作者：
Anqin Xu;J. Harb;M. Kostiainen;W. Hughes;A. Woolley;Haitao Liu;A. Gopinath
在过去的十年里，DNA折纸已经成熟为最强大的自下而上的纳米制造技术之一。它既可以制造任意二维或三维形状的纳米颗粒，也可以在∼5 nm分辨率下对任何与DNA连接的纳米材料进行空间组织，如碳纳米管、量子点或蛋白质。虽然DNA折纸在DNA纳米技术界得到了广泛的应用，但它还没有广泛应用于材料科学和设备物理，这两个领域现在主要依赖于自上而下的纳米制造。在这篇文章中，我们首先介绍DNA折纸作为纳米材料的模块面包板，然后简要综述最近的结果，展示DNA折纸与现有自上而下技术相结合所创造的独特能力。重点是与每种方法相关的开放挑战，我们建议潜在的下一步，从最近在材料科学和设备物理方面的工作中获得灵感。最后，我们讨论了DNA折纸和自上而下的纳米制造的结合可能带来的一些近期应用。
Over the last decade, DNA origami has matured into one of the most powerful bottom-up nanofabrication techniques. It enables both the fabrication of nanoparticles of arbitrary two-dimensional or three-dimensional shapes, and the spatial organization of any DNA-linked nanomaterial, such as carbon nanotubes, quantum dots, or proteins at ∼5-nm resolution. While widely used within the DNA nanotechnology community, DNA origami has yet to be broadly applied in materials science and device physics, which now rely primarily on top-down nanofabrication. In this article, we first introduce DNA origami as a modular breadboard for nanomaterials and then present a brief survey of recent results demonstrating the unique capabilities created by the combination of DNA origami with existing top-down techniques. Emphasis is given to the open challenges associated with each method, and we suggest potential next steps drawing inspiration from recent work in materials science and device physics. Finally, we discuss some near-term applications made possible by the marriage of DNA origami and top-down nanofabrication.