Protection of N-methyl-N′-nitro-N-nitrosoguanidine-induced in vivo clastogenicity by aqueous garlic extract
Protection of N-methyl-N′-nitro-N-nitrosoguanidine-induced in vivo clastogenicity by aqueous garlic extract
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DOI：
10.1046/j.1440-6047.2001.00249.x
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发表时间：
2001-01-01
影响因子：
1.3
通讯作者：
Ramesh, A
中科院分区：
文献类型：
--
作者：
Arivazhagan, S;Nagini, S;Ramesh, A
通过对雄性Wistar大鼠骨髓中期细胞微核和染色体畸变的定量分析，评价了大蒜提取物对致癌亚硝胺N-甲基-N '-硝基-N-亚硝基胍（MNNG）体内致染色体断裂的调节作用。单次腹腔注射MNNG（40 mg/kg体重）具有致染色体断裂性，表现为微核嗜多染红细胞和染色体畸变频率增加。大蒜水提取物（250 mg/kg体重）预处理5天显着降低MNNG诱导的微核和染色体畸变的频率。结果表明，大蒜提取物的管理保护对MNNG的致染色体断裂作用。
The modulatory effects of garlic extract on the in vivo clastogenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a carcinogenic nitrosamine, were evaluated by quantification of micronuclei and chromosomal aberrations in metaphase cells from the bone marrow of male Wistar rats. A single intraperitoneal injection of MNNG (40 mg/kg bodyweight) was found to be clastogenic as revealed by the increased frequency of micronucleated polychromatic erythrocytes and chromosomal aberrations. Pretreatment with aqueous garlic extract (250 mg/kg bodyweight) for 5 days significantly reduced the frequencies of MNNG-induced micronuclei and chromosomal aberrations. The results demonstrate that administration of garlic extract protects against the clastogenic effects of MNNG.