A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans.
A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans.
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DOI：
10.1155/2013/410395
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发表时间：
2013
影响因子：
1.9
通讯作者：
Gill J
中科院分区：
文献类型：
--
作者：
Brockie TN;Heinzelmann M;Gill J
背景。美洲原住民不成比例地经历过不良童年经历 (ACE) 以及健康差异，包括高比例的创伤后应激、抑郁和药物滥用。许多 ACE 与调节应激反应的基因甲基化变化有关，这表明这些分子变化可能是与 ACE 相关的精神疾病风险的基础。方法。我们回顾了已发表的研究，以提供证据表明 ACE 相关的甲基化变化会导致美洲原住民的健康差异。该框架可用于了解 ACE 如何导致其他种族/族裔群体的健康差异。发现。在这里，我们提供了证据，证明 ACE 与调节应激反应的基因甲基化差异有关。精神疾病还与内分泌、免疫和神经递质基因的甲基化差异有关，这些基因用于调节应激反应，并与精神症状和医学发病率相关。我们提供了将 ACE 与这些表观遗传修饰联系起来的证据，表明 ACE 导致美洲原住民更容易患上精神疾病。结论。需要进行更多研究来更好地了解 ACE 如何促进健康和福祉。这些研究可能为未来的干预措施提供信息，以解决这些严重风险并促进美洲原住民的健康和福祉。
Background. Native Americans disproportionately experience adverse childhood experiences (ACEs) as well as health disparities, including high rates of posttraumatic stress, depression, and substance abuse. Many ACEs have been linked to methylation changes in genes that regulate the stress response, suggesting that these molecular changes may underlie the risk for psychiatric disorders related to ACEs. Methods. We reviewed published studies to provide evidence that ACE-related methylation changes contribute to health disparities in Native Americans. This framework may be adapted to understand how ACEs may result in health disparities in other racial/ethnic groups. Findings. Here we provide evidence that links ACEs to methylation differences in genes that regulate the stress response. Psychiatric disorders are also associated with methylation differences in endocrine, immune, and neurotransmitter genes that serve to regulate the stress response and are linked to psychiatric symptoms and medical morbidity. We provide evidence linking ACEs to these epigenetic modifications, suggesting that ACEs contribute to the vulnerability for developing psychiatric disorders in Native Americans. Conclusion. Additional studies are needed to better understand how ACEs contribute to health and well-being. These studies may inform future interventions to address these serious risks and promote the health and well-being of Native Americans.