Influence of physical fitness on antioxidant activity and malondialdehyde level in healthy older adults
Influence of physical fitness on antioxidant activity and malondialdehyde level in healthy older adults
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DOI：
10.1139/apnm-2014-0417
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发表时间：
2015-06-01
影响因子：
3.4
通讯作者：
Fabre, Claudine
中科院分区：
文献类型：
--
作者：
Bouzid, Mohamed Amine;Hammouda, Omar;Fabre, Claudine
本研究的目的是探讨身体素质水平如何影响健康老年人在休息和力竭运动时的抗氧化活性和丙二醛（MDA）水平。50名老年人（平均年龄：66.1 ± 3.8岁）根据他们的身体素质水平分为不健康组（UG）（n = 15），低健康水平组（LFG）（n = 18），和高健康水平组（HFG）（n = 17）。健康状况是根据过去12个月内对体育活动问卷的回答进行分类的。之前和之后的增量自行车测力计测试耗尽，以下标志物进行了评估：超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPX），谷胱甘肽还原酶，抗坏血酸，α-生育酚，和MDA。静息时，超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）和α-生育酚（α-生育酚）活性在高脂饲料组高于其他两组（p <0.05），而丙二醛（MDA）水平在低脂饲料组低于其他两组（p < 0.05）。在运动后期间，抗氧化活性仅在LFG和HFG（GPX，SOD和α-生育酚）中增加。运动后各组MDA水平均升高（P < 0.05）。此外，在恢复期，高脂饲料组的MDA水平高于其他组。这项研究的结论是，低和高的身体健康水平都有助于老年人保持更好的抗氧化防御。然而，较高的体能水平，而不是较低的体能水平，会增加脂质过氧化作用。
The aim of this study was to investigate how physical fitness level could affect antioxidant activity and malondialdehyde (MDA) level at rest and in response to exhaustive exercise in healthy older adults. Fifty older adults (average age: 66.1 +/- 3.8 years) were divided according to their physical fitness level into an unfit group (UG) (n = 15), a low fitness level group (LFG) (n = 18), and a high fitness level group (HFG) (n = 17). Fitness status was classified based on answers to a questionnaire about physical activity in the previous 12 months. Before and after an incremental cycle ergometer test to exhaustion, the following markers were assessed: superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase, ascorbic acid, alpha-tocopherol, and MDA. At rest, SOD, GPX, and alpha-tocopherol activities were higher in the HFG (p < 0.05), whereas MDA level was lower in the LFG in comparison with the 2 other groups (p < 0.05). During the postexercise period, antioxidant activity increased only in the LFG and the HFG (GPX, SOD, and alpha-tocopherol). MDA level increased in all groups after the exercise (p < 0.05). In addition, MDA level was higher during the recovery period in the HFG as compared with the others groups. This study concluded that both low and high physical fitness levels help maintain better antioxidant defenses in older adults. However, a higher physical fitness level, rather than a lower physical fitness level, could increase lipid peroxidation.