BOLD signal in insula is differentially related to cardiac function during compassion meditation in experts vs. novices
BOLD signal in insula is differentially related to cardiac function during compassion meditation in experts vs. novices
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DOI：
10.1016/j.neuroimage.2009.04.081
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发表时间：
2009-09-01
期刊：
影响因子：
5.7
通讯作者：
Davidson, Richard J.
中科院分区：
文献类型：
--
作者：
Lutz, Antoine;Greischar, Lawrence L.;Davidson, Richard J.
大脑和心血管系统在情绪处理过程中相互影响。尽管这些系统对身体健康具有潜在的重要性，但对情绪调节过程中这些系统相互作用的研究在人类功能神经影像学方面仍受到限制。我们之前曾报道过，培养同情心的心理专业知识会改变与同理心和心理理论相关的回路的激活，以应对情绪刺激。在慈悲冥想块期间心率比中性状态增加更多这一发现的指导下，特别是对于专家而言，我们检查了状态（慈悲与中性）和组（新手、专家）之间的相互作用，以了解在每种状态期间呈现的情绪声音呈现期间心率与 BOLD 信号之间的关系。我们的研究结果表明，右中岛叶中的 BOLD 信号与各州和各组的心率 (HR) 显着相关。当专家与新手进行比较时，这种关联在左中/后岛叶中更强。对于两组来说，在同情状态下，HR 和 BOLD 的正耦合高于在背侧前扣带皮层的中性状态下，强调了该区域在调节身体唤醒状态中的作用。在体感皮层和右顶下小叶（按状态相互作用分组）中，专家的这种状态效应比新手更强。这些数据证实，同情心增强了他人情绪的情绪和体感大脑表征，并且这种效应受到专业知识的调节。未来的研究需要进一步调查同情心训练对这些回路的影响。 (C) 2009 Elsevier Inc. 保留所有权利。
The brain and the cardiovascular system influence each other during the processing of emotion. The study of the interactions of these systems during emotion regulation has been limited in human functional neuroimaging, despite its potential importance for physical health. We have previously reported that mental expertise in cultivation of compassion alters the activation of circuits linked with empathy and theory of mind in response to emotional stimuli. Guided by the finding that heart rate increases more during blocks of compassion meditation than neutral states, especially for experts, we examined the interaction between state (compassion vs. neutral) and group (novice, expert) on the relation between heart rate and BOLD signal during presentation of emotional Sounds presented during each state. Our findings revealed that BOLD signal in the right middle insula showed a significant association with heart rate (HR) across state and group. This association was stronger in the left middle/posterior insula when experts were compared to novices. The positive coupling of HR and BOLD was higher within the compassion state than within the neutral state in the dorsal anterior cingulate cortex for both groups, underlining the role of this region in the modulation of bodily arousal states. This state effect was stronger for experts than novices in somatosensory cortices and the right inferior parietal lobule (group by state interaction). These data confirm that compassion enhances the emotional and somatosensory brain representations of others' emotions, and that this effect is modulated by expertise. Future studies are needed to further investigate the impact of compassion training on these circuits. (C) 2009 Elsevier Inc. All rights reserved.