Probing disaccharide selectivity with modular fluorescent sensors
Probing disaccharide selectivity with modular fluorescent sensors
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DOI：
10.1016/j.tetlet.2003.12.013
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发表时间：
2004-02-09
影响因子：
1.8
通讯作者：
James, TD
中科院分区：
文献类型：
--
作者：
Arimori, S;Phillips, MD;James, TD
六个模块化的光诱导电子转移（PET）传感器轴承两个苯基硼酸受体已被评估为荧光二糖传感器。改变分离两个硼酸部分的接头的长度，并通过荧光光谱法评估传感器与二糖的相互作用。结果表明，糖的选择性受到接头长度的选择的影响。二硼酸传感器3（n）还显示出对连接到第3或第6位上的碳的二糖（如从异头中心编号的）的显著特异性超过连接在第4位上的那些。(C)2003 Elsevier Ltd.保留所有权利。
Six modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid receptors have been evaluated as fluorescent disaccharide sensors. The length of linker separating the two boronic acid moieties was varied and the sensors' interaction with disaccharides assessed via fluorescence spectroscopy. It was shown that saccharide selectivity was influenced by the choice of linker length. Diboronic acid sensors 3(n) also displayed significant specificity for the disaccharides linked to the carbon on the 3rd or 6th position (as numbered from the anomeric centre) over those linked at the 4th position. (C) 2003 Elsevier Ltd. All rights reserved.