Blood-Brain Barrier Function and Biomarkers of Central Nervous System Injury in Rickettsial Versus Other Neurological Infections in Laos.
Blood-Brain Barrier Function and Biomarkers of Central Nervous System Injury in Rickettsial Versus Other Neurological Infections in Laos.
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DOI：
10.4269/ajtmh.15-0119
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Turner GDH
中科院分区：
文献类型：
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作者：
Dittrich S;Sunyakumthorn P;Rattanavong S;Phetsouvanh R;Panyanivong P;Sengduangphachanh A;Phouminh P;Anantatat T;Chanthongthip A;Lee SJ;Dubot-Pérès A;Day NPJ;Paris DH;Newton PN;Turner GDH
对老挝人民民主共和国入院的严重神经系统感染患者（N = 66）进行血脑屏障（BBB）功能和脑脊液（CSF）生物标志物测量，包括细菌性脑膜炎（BM；N = 9）或结核性脑膜炎（TBM；N = 11）、日本脑炎病毒（JEV；N = 25）和立克次体感染（N = 21）包括鼠型斑疹伤寒和恙虫病患者。 BM 和 TBM 中的白蛋白指数 (AI) 和神经胶质纤维酸性蛋白 (GFAP) 水平显着高于其他疾病，但在个体立克次体患者中也升高。 JEV患者脑脊液中的总tau蛋白显着升高。与立克次体相比，临床或神经症状、AI 或生物标志物水平之间没有发现差异，可以区分恙虫病东方体严重神经系统受累。
Blood–brain barrier (BBB) function and cerebrospinal fluid (CSF) biomarkers were measured in patients admitted to hospital with severe neurological infections in the Lao People's Democratic Republic (N = 66), including bacterial meningitis (BM; N = 9) or tuberculosis meningitis (TBM; N = 11), Japanese encephalitis virus (JEV; N = 25), and rickettsial infections (N = 21) including murine and scrub typhus patients. The albumin index (AI) and glial fibrillary acidic protein (GFAP) levels were significantly higher in BM and TBM than other diseases but were also raised in individual rickettsial patients. Total tau protein was significantly raised in the CSF of JEV patients. No differences were found between clinical or neurological symptoms, AI, or biomarker levels that allowed distinction between severe neurological involvement by Orientia tsutsugamushi compared with Rickettsia species.