HIV infection and lymphoma
HIV infection and lymphoma
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DOI：
10.1136/jcp.2007.051953
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发表时间：
2007-12-01
影响因子：
3.4
通讯作者：
Dogan, A.
中科院分区：
文献类型：
--
作者：
Grogg, K. L.;Miller, R. F.;Dogan, A.
HIV感染者淋巴瘤的发病率大大超过一般人群。淋巴瘤的风险增加似乎与多种因素有关，包括逆转录病毒本身的转化特性，由疾病引起的免疫抑制和细胞因子失调，以及最重要的是，其他嗜淋巴细胞疱疹病毒如EB病毒和人类疱疹病毒8的机会性感染。组织学上的淋巴瘤分为三类：（1）也发生在免疫功能正常的患者中的淋巴瘤;（2）更具体地发生在HIV阳性患者中的淋巴瘤;以及（3）也发生在其他形式的免疫抑制患者中的淋巴瘤。侵袭性淋巴瘤占绝大多数病例。他们经常表现为晚期，巨大的疾病与高肿瘤负荷，通常涉及结节部位。临床结果似乎比一般人群中类似的侵袭性淋巴瘤更差。然而，在引入高效抗逆转录病毒疗法后，在艾滋病毒感染的情况下发生淋巴瘤的风险降低了，临床结果也得到了改善。
The incidence of lymphoma in patients with HIV infection greatly exceeds that of the general population. The increased risk for lymphoma appears related to multiple factors, including the transforming properties of the retrovirus itself, the immunosuppression and cytokine dysregulation that results from the disease, and, most importantly, opportunistic infections with other lymphotrophic herpes viruses such as Epstein-Barr virus and human herpesvirus 8. Histologically lymphomas fall into three groups: (1) those also occurring in immunocompetent patients; (2) those occurring more specifically in HIV-positive patients; and (3) those also occurring in patients with other forms of immunosuppression. Aggressive lymphomas account for the vast majority cases. They frequently present with advanced stage, bulky disease with high tumour burden and, typically, involve extranodal sites. Clinical outcome appears to be worse than in similar aggressive lymphomas in the general population. However, following the introduction of highly active antiretroviral therapy, the risk for developing lymphoma in the context of HIV infection has decreased and the clinical outcome has improved.