EPIDEMIOLOGY OF ENDOMETRIOSIS AMONG PAROUS WOMEN
EPIDEMIOLOGY OF ENDOMETRIOSIS AMONG PAROUS WOMEN
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DOI：
10.1016/0029-7844(95)00074-2
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发表时间：
1995-06-01
影响因子：
7.2
通讯作者：
POINDEXTER, AN
中科院分区：
文献类型：
--
作者：
SANGIHAGHPEYKAR, H;POINDEXTER, AN
目的：报告子宫内膜异位症的患病率及其相关的危险因素之间的多产妇女，并确定这种疾病的位置和深度和一定的医疗和行为characteristics.Methods：在6年的时间内，3384多产妇女进行腹腔镜输卵管绝育术之间的关系。在126名患者（3.7%）中检测到子宫内膜异位症，随后对疾病的严重程度进行了评估。为了进行病例对照研究，从一组接受绝育手术的妇女中随机选择了504例无子宫内膜异位症证据的患者。通过体格检查和自填问卷获得的信息进行了多因素Logistic回归分析。与子宫内膜异位症风险增加相关的因素包括：高龄（比值比[OR] 2.0，95%置信区间[CI] 1.1-3.7），亚洲人种（OR 8.6，95% CI 1.4-20.1），周期长（OR 1.8，95% CI 1.1-2.7），1例活产（OR 2.2，95% CI 1.1-4.3），长期使用宫内节育器（OR 3.0，95% CI 1.1-8.1）和月经周期持续时间长（OR 2.9，95% CI 1.3-6.4）。目前口服避孕药的使用对疾病具有保护作用（OR 0.5，95% CI 0.2-0.9）。这些因素的作用在不同的疾病部位（卵巢，子宫和输卵管，后阔韧带和子宫陷凹）和深度（浅表或深）之间存在差异。结论：子宫内膜异位症的患病率在经产妇女中相对较低，某些月经和生殖特征与其发展相关。此外，各种因素与子宫内膜异位症之间的关系似乎是部位和深度特异性的。我们的研究结果表明，无症状的子宫内膜异位症可能是临床上重要的。
Objective: To report the prevalence of endometriosis and its associated risk factors among multiparous women, and to determine the relationship between the location and depth of this disease and certain medical and behavioral characteristics.Methods: Over a 6-year period, 3384 multiparous women underwent laparoscopy for tubal sterilization. Endometriosis was detected in 126 patients (3.7%), who were consequently evaluated for severity of the disease. To conduct a case-control study, 504 patients with no evidence of endometriosis were randomly selected from a group of women who underwent sterilization. Information obtained through physical examination and a self-administered questionnaire was studied by multivariate logistic regression analysis.Results: Most endometriosis lesions were minimal. Factors associated with an increased risk for endometriosis included: advanced age (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.1-3.7), Asian race (OR 8.6, 95% CI 1.4-20.1), long cycle length (OR 1.8, 95% CI 1.1-2.7), one live birth (OR 2.2, 95% CI 1.1-4.3), long duration of intrauterine device use (OR 3.0, 95% CI 1.1-8.1), and long duration of uninterrupted menstrual cycles (OR 2.9, 95% CI 1.3-6.4). Present oral contraceptive use was protective for disease (OR 0.5, 95% CI 0.2-0.9). The role of these factors varied among different disease locations (ovary, uterus and tubes, posterior broad ligaments and cul-de-sac), and depth (superficial or deep).Conclusions: The prevalence of endometriosis is relatively low among multiparous women, and certain menstrual and reproductive characteristics are associated with its development. Furthermore, the relationship between various factors and endometriosis appears to be site and depth specific. Our findings suggest that asymptomatic endometriosis may be clinically important.