Risk of carotid atherosclerosis associated with genetic polymorphisms of apoliploprotein E and inflammatory genes among arsenic exposed residents in Taiwan
Risk of carotid atherosclerosis associated with genetic polymorphisms of apoliploprotein E and inflammatory genes among arsenic exposed residents in Taiwan
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DOI：
10.1016/j.taap.2007.10.013
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发表时间：
2008-02-15
影响因子：
3.8
通讯作者：
Chen, Chien-Jen
中科院分区：
文献类型：
--
作者：
Hsieh, Yi-Chen;Hsieh, Fang-I;Chen, Chien-Jen
砷已被报道与颈动脉粥样硬化。然而，很少有研究来评估砷暴露居民中脂代谢和炎症易感基因与颈动脉粥样硬化之间的关联。本研究的目的是探讨载脂蛋白E和单核细胞趋化蛋白-1基因多态性与台湾兰阳盆地居民颈动脉粥样硬化风险之间的关系，这是一个新确认的砷流行区。总共有479名居民被这两个基因分型并检查了颈动脉粥样硬化的严重程度。颈动脉内膜中层厚度（IMT）≥ 1.0 mm或颅外段颈动脉可见斑块者诊断为颈动脉粥样硬化。APOE基因EA等位基因携带者发生颈动脉粥样硬化的年龄和性别校正优势比为2.0，显著高于无等位基因携带者。与携带APOE和MCP-1野生型的研究对象相比，在校正年龄和性别后，携带APOE和MCP-1两种风险基因型的研究对象发生颈动脉粥样硬化的风险为2.5倍，揭示了这些基因的风险基因型数量与颈动脉粥样硬化风险之间的显著剂量反应关系。此外，具有APOE和MCP-1两种风险基因型的研究对象，无论是摄入砷水平>10 μ g/L的井水还是砷暴露>0.22 mg/L-年，发生颈动脉粥样硬化的风险分别为10.3倍和15.7倍，显示出砷暴露和APOE和MCP-1风险基因型的显著联合效应。(C)2007年爱思唯尔公司All rights reserved.
Arsenic had been reported to be associated with carotid atherosclerosis. However, there were few studies to evaluate the association between the susceptible gene of lipid metabolism and inflammation and carotid atherosclerosis among arsenic exposure residents. The aim of the study was to investigate the associations between the genetic polymorphisms of APOE and MCP-1 and the risk of carotid atherosclerosis among residents of Lanyang Basin in Taiwan which was a newly confirmed arsenic-endemic area. In total, 479 residents who had been genotyped of these two genes and examined the severity of carotid atherosclerosis were included in this study. The study subjects with carotid intima media thickness (IMT) >= 1.0 mm or with the observable plaque in the extracranial carotid artery were diagnosed as carotid atherosclerosis. A significantly age- and gender-adjusted odds ratio of 2.0 for the development of carotid atherosclerosis was observed in study subjects with EA allele of APOE than those without epsilon 4 allele. Compared with study subjects who carried wild genotypes of APOE and MCP-1, those with both risk genotypes of APOE and MCP-1 had 2.5-fold risk of carotid atherosclerosis after adjustment for age and gender, revealing a significant dose-response relationship between number of risk genotypes of these genes and risk of carotid atherosclerosis. Additionally, study subjects with two risk genotypes of APOE and MCP-1 and either had ingested well water contained arsenic level >10 mu g/L or had arsenic exposure >0.22 mg/L-year would have strikingly highest risk of 10.3-fold and 15.7-fold, respectively, for the development carotid atherosclerosis, showing significant joint effect of arsenic exposure and risk genotypes of APOE and MCP-1. (C) 2007 Elsevier Inc. All rights reserved.