An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature.
An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature.
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DOI：
10.3390/ijms18020297
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发表时间：
2017-01-29
影响因子：
5.6
通讯作者：
Caron N
中科院分区：
文献类型：
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作者：
Jadot I;Declèves AE;Nortier J;Caron N
术语“马兜铃酸肾病”（AAN）用于包括任何形式的毒性间质性肾病，其由作为传统植物疗法的一部分的含有马兜铃酸（AA）的植物的摄入（以前称为“中草药肾病”）或由食物中的环境污染物（巴尔干半岛的地方性肾病）引起。它经常与尿路上皮恶性肿瘤有关。虽然大多数国家已禁止使用含有AA的产品，但AAN病例仍在世界各地定期报告。此外，AAN的发病率可能被高度低估，因为AA存在于世界各地的传统草药和疾病的认识薄弱。在过去的二十年中，AAN的动物模型已经被开发出来，以研究AAN发病机制中涉及的潜在分子和细胞机制。事实上，更深入地了解这些过程对于制定旨在减少这种疾病的全球和被低估的负担的治疗策略至关重要。在这方面，我们的目的是建立一个广泛的概述，目前已知的AAN。为了实现这一目标，我们的目的是总结有关导致AAN发展的潜在病理生理学机制的最新数据，特别强调血管活性因子之间的不平衡，以及关注AAN中通常不考虑的血管事件。
The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as “Chinese herbs nephropathy”), or by the environmental contaminants in food (Balkan endemic nephropathy). It is frequently associated with urothelial malignancies. Although products containing AA have been banned in most of countries, AAN cases remain regularly reported all over the world. Moreover, AAN incidence is probably highly underestimated given the presence of AA in traditional herbal remedies worldwide and the weak awareness of the disease. During these two past decades, animal models for AAN have been developed to investigate underlying molecular and cellular mechanisms involved in AAN pathogenesis. Indeed, a more-in-depth understanding of these processes is essential to develop therapeutic strategies aimed to reduce the global and underestimated burden of this disease. In this regard, our purpose was to build a broad overview of what is currently known about AAN. To achieve this goal, we aimed to summarize the latest data available about underlying pathophysiological mechanisms leading to AAN development with a particular emphasis on the imbalance between vasoactive factors as well as a focus on the vascular events often not considered in AAN.