Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China
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DOI：
10.1038/aps.2011.84
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发表时间：
2011-11-01
影响因子：
8.2
通讯作者：
Shi, Yong-quan
中科院分区：
文献类型：
--
作者：
Tang, Wei;Zou, Jun-jie;Shi, Yong-quan
目的：SOCS3基因在动物模型肥胖发病机制中发挥重要作用，但人体研究数据相对有限。针对这一问题，我们对生活在相似环境条件下的不同遗传背景的民族进行了遗传关联分析。方法：从中国新疆哈萨克族、维吾尔族和汉族中随机招募2711名受试者。使用TaqMan-MGB (TM) 测定法对SOCS3基因内或附近的SNP多态性rs4969168和rs9892622进行基因分型。对这两个多态性与肥胖相关性状（体重指数[BMI]；腰臀比[WHR]；体重；身高、腰围和臀围测量值）之间进行关联研究。结果：rs4969168与肥胖相关性状之间发现显着关联，包括BMI（AA为25.32+/-3.49 kg/m(2)， AG 24.60 +/- 3.70 kg/m(2)，GG 24.39 +/- 3.42 kg/m(2)，P=0.042)，重量（AA 65.58 +/- 11.42 kg，AG 63.50 +/- 11.30 kg，GG 62.00 +/- 10.78 kg， P=0.011）在汉族中，但在哈萨克族中没有 或维吾尔族。 Rs9892622 与维吾尔族男性的 BMI、WHR 和 WAIST 显着相关。 Rs9892622 也与哈萨克男性的 BMI 相关。线性回归分析验证了上述结果。然而，这两个多态性均与总人群中的肥胖相关性状无关。结论：SOCS3基因内或附近的多态性rs4969168在汉族中具有显着影响，而rs9892622与中国新疆维吾尔族和哈萨克族的肥胖相关。
Aim: SOCS3 gene plays an important role in the pathogenesis of obesity in animal models, but the data from human studies are relatively limited. To address this issue, a genetic association analysis on nationalities with different genetic background living in the similar environmental conditions was performed.Methods: Two thousand seven hundred eleven subjects were randomly recruited from the Kazakh, Uygur and Han nationalities in Xin-jiang of China. SNP polymorphisms rs4969168 and rs9892622 within or near the SOCS3 gene were genotyped using TaqMan-MGB (TM) assay. Association study between the two polymorphisms and obesity-related traits (body mass index [BMI]; waist-to-hip ratio [WHR]; weight; height, waist, and hip measurements) was conducted.Results: Significant association was found between rs4969168 and the obesity-related traits, including BMI (25.32 +/- 3.49 kg/m(2) for AA, 24.60 +/- 3.70 kg/m(2) for AG, 24.39 +/- 3.42 kg/m(2) for GG, P=0.042), weight (65.58 +/- 11.42 kg for AA, 63.50 +/- 11.30 kg for AG, 62.00 +/- 10.78 kg for GG, P=0.011) in the Han nationality, but not in the Kazakh or Uygur nationalities. Rs9892622 was significantly associated with BMI, WHR, and WAIST in the Uygur males. Rs9892622 was also associated with BMI in Kazakh males. Linear regression analysis verified the above findings. However, neither of the two polymorphisms was associated with obesity-related traits in the total population.Conclusion: The polymorphism rs4969168 within or near the SOCS3 gene has a significant effect in the Han nationality, while rs9892622 was associated with obesity in Uygur and Kazakh nationalities in Xinjiang of China.