PREEXISTING LUNG-DISEASE AND LUNG-CANCER AMONG NONSMOKING WOMEN
PREEXISTING LUNG-DISEASE AND LUNG-CANCER AMONG NONSMOKING WOMEN
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DOI：
10.1093/oxfordjournals.aje.a116542
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发表时间：
1992-09-15
影响因子：
5
通讯作者：
HOCK, E
中科院分区：
文献类型：
--
作者：
ALAVANJA, MCR;BROWNSON, RC;HOCK, E
1986年6月1日至1991年4月1日，在密苏里州对不吸烟妇女进行了一项基于人群的病例对照研究，将既往存在的肺部疾病作为肺癌的危险因素。618例病例中约41%和1，402例对照中约35%报告了肺部疾病史（比值比（OR）= 1.2; 95%置信区间（Cl）1.0-1.5）。当排除近亲访谈时，风险更明显（OR = 1.5）。既往肺部疾病与腺癌（OR = 1.4）（占癌症的62%）和所有其他细胞类型的肺癌（OR = 1.8）均显著相关。尽管戒烟超过15年，但长期戒烟者患肺癌的风险是终身不吸烟者的2.2倍。在终生不吸烟者中，哮喘（OR = 2.7）和肺炎（OR = 1.5）的风险显著。肺气肿（OR = 2.6）和肺结核（OR = 2.0）也与肺癌显著相关，但仅限于既往吸烟者。慢性支气管炎仅与非腺癌风险升高相关（OR = 2.3）。胸膜炎的病例报告频率并不比对照组高。在不吸烟的妇女中，大约16%的肺癌可归因于以前的肺部疾病，最主要的是哮喘、肺炎、肺气肿和肺结核。
Preexisting lung disease was examined as a risk factor for lung cancer in a population-based, case-control study of nonsmoking women in Missouri conducted between June 1, 1986, and April 1, 1991. A history of lung disease was reported by approximately 41 % of 618 cases and 35% of 1,402 controls (odds ratio (OR) = 1.2; 95% confidence interval (Cl) 1.0-1.5. The risk was more pronounced when next-of-kin interviews were excluded (OR = 1.5). Previous lung disease was significantly related both to adenocarcinoma (OR = 1.4), which accounted for 62% of the cancers, and to all other cell types of lung cancer combined (OR = 1.8). Despite having discontinued smoking for more than 15 years, long-term ex-smokers were at a 2.2-fold risk of lung cancer compared with lifetime nonsmokers. Among lifetime nonsmokers, significant risks were noted for asthma (OR = 2.7) and pneumonia (OR = 1.5). Emphysema (OR = 2.6) and tuberculosis (OR = 2.0) were also significantly related to lung cancer, but only among former smokers. Chronic bronchitis was linked to elevated risks of nonadenocarcinomas only (OR = 2.3). Pleurisy was not reported more frequently by cases than by controls. Approximately 16% of all lung cancers among nonsmoking women could be attributed to previous lung diseases, most notably asthma, pneumonia, emphysema, and tuberculosis.