In vitro antimalarial activity of a Thai medicinal plant Picrasma javanica Bl
In vitro antimalarial activity of a Thai medicinal plant Picrasma javanica Bl
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泰国药用植物 Picrasma javanica Bl 的体外抗疟活性
DOI：
10.1002/ptr.2650020105
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Jaree Bansiddhi
中科院分区：
文献类型：
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作者：
K. Pavanand;K. Yongvanitchit;H. Webster;T. Dechatiwongse;W. Nutakul;Yenchit Jewvachdamrongkul;Jaree Bansiddhi
苦木，对传统医学中用于治疗疟疾的药用植物的抗疟活性进行了评价。初步筛选表明，树皮的氯仿提取物具有最高的抗疟活性。化学分离和纯化的活性生物碱部分产生了三个不同的纯生物碱成分。其中，一种成分被鉴定为已知的主要树皮生物碱，4-甲氧基-1-乙烯基-β-咔啉，第二种新生物碱，6-羟基-4-甲氧基-1-乙烯基-β-咔啉。剩余生物碱的完全表征是不可能的，由于其低产率。这两种已鉴定的生物碱对恶性疟原虫的多药耐药泰国分离株显示出体外抗疟活性。
Picrasma javanica Bl., a medicinal plant used for the treatment of malaria in traditional medicine was evaluated for antimalarial activity. Primary screening demonstrated that the chloroform extract of the bark possessed the highest yield of antimalarial activity. Chemical isolation and purification of the active alkaloidal part yielded three different pure alkaloid components. Among these, one component was identified as the known major bark alkaloid, 4‐methoxy‐1‐vinyl‐β‐carboline, and a second new alkaloid, 6‐hydroxy‐4‐methoxy‐1‐vinyl‐β‐carboline. Complete characterization of the remaining alkaloid was not possible due to its inferior yield. The two identified alkaloids showed in vitro antimalarial activity against multi‐drug resistant Thai isolates of Plasmodium falciparum.