Studying NF-κB signaling with mathematical models.
Studying NF-κB signaling with mathematical models.
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用数学模型研究 NF-κB 信号传导。
DOI：
10.1007/978-1-4939-2422-6_38
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hoffmann,Alexander
中科院分区：
文献类型：
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作者：
Mitchell,Simon;Tsui,Rachel;Hoffmann,Alexander
NF-κB信号传导的数学模型可以用来理解分子相互作用网络如何导致实验观察到的信号传导现象。模型构建是一个具有挑战性的过程；然而，现有的模型可以被利用，并且可以快速而廉价地提供大量的洞察力。这里详细介绍了使用数学模型模拟各种输入和识别潜在治疗靶点的方法。
Mathematical modeling of NF-κB signaling can be employed to understand how the network of molecular interactions leads to signaling phenomena observed experimentally. Model construction is a challenging process; however, existing models can be utilized and can provide a great deal of insight quickly and inexpensively. The simulation of various inputs and the identification of potential therapeutic targets using the mathematical model are detailed here.