Development and validation of the Vitiligo Extent Score for a Target Area (VESTA) to assess the treatment response of a target lesion.
Development and validation of the Vitiligo Extent Score for a Target Area (VESTA) to assess the treatment response of a target lesion.
复制标题
开发和验证目标区域白癜风程度评分 (VESTA)，以评估目标病变的治疗反应。
DOI：
10.1111/pcmr.12730
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Lee SC; East Asia Vitiligo Association.
中科院分区：
文献类型：
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作者：
Bae JM;Oh SH;Kang HY;Ryoo YW;Lan CE;Xiang LH;Kim KH;Suzuki T;Katayama I;Lee SC; East Asia Vitiligo Association.
由于白癜风的局部治疗与全身治疗一样重要，因此除了全身评估外，还需要一种可靠的目标评估工具。我们使用边缘和毛囊周围色素沉着的参考图像开发了目标区域的白癜风程度评分（VESTA），以测量目标病变中的色素沉着率（%）。在验证研究中，10个研究所的65名皮肤科医生使用粗略估计和VESTA评估了17对白癜风图像（治疗前和治疗后）。VESTA（一致性相关系数：0.949，95%置信区间[CI] 0.942-0.955）的准确度显著高于粗略估计值（0.896，95% CI：0.883-0.908）。与粗略估计相比，它还与更好的评定者间可靠性相关，尽管不显著。VESTA可以提供直观、方便和可靠的靶区域治疗反应评估，在临床实践和回顾性研究中非常有用。
Since localized treatment for vitiligo is as essential as systemic treatment, a reliable instrument for target evaluation is needed besides those for whole body evaluation. We developed the Vitiligo Extent Score for a Target Area (VESTA) using reference images of both marginal and perifollicular repigmentation to measure the repigmentation rate (%) in a target lesion. In the validation study, a total of 65 dermatologists in 10 institutes evaluated 17 pairs of vitiligo images (pre‐ and post‐treatment) using both a rough estimate and the VESTA. The VESTA (concordance correlation coefficient: 0.949, 95% confidence interval [CI] 0.942–0.955) was significantly more accurate than the rough estimate (0.896, 95% CI: 0.883–0.908). It was also associated with better inter‐rater reliability over the rough estimate, albeit not significant. The VESTA can afford intuitive, convenient, and reliable assessment of the treatment response in a target area, and would be useful in clinical practice as well as retrospective studies.