The limitations of evidence: increasing data and increasing doubt in the treatment of cardiac arrest.
The limitations of evidence: increasing data and increasing doubt in the treatment of cardiac arrest.
复制标题
证据的局限性：心脏骤停治疗中的数据不断增加，质疑不断增加。
DOI：
10.1097/mcc.0000000000000765
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发表时间：
2020
影响因子：
3.3
通讯作者：
Berg,KatherineM
中科院分区：
文献类型：
--
作者：
Berg,KatherineM
多项主要心脏骤停干预措施的试验，包括温度管理、心肺复苏（CPR）期间的药物和气道管理，现在已经有了高质量的随机试验，但在疗效和最佳做法方面仍然存在重大问题。探讨了常见的陷阱和原因，包括患者和提供者的异质性，所研究的确切干预措施的可变性，开始研究干预措施的延迟以及围绕复苏适当性决策的跨系统缺乏一致性。
Trials on multiple major cardiac arrest interventions, including temperature management, drugs during cardiopulmonary resuscitation (CPR) and airway management, now have high-quality randomized trials, but significant questions on efficacy and best practices remain. Common pitfalls and reasons for this are explored, including heterogeneity of patients and providers, variability in exact interventions studied, delay in starting research interventions and lack of consistency across systems in decision making around appropriateness for resuscitation.