CONCENTRATIONS OF ATRACURIUM AND LAUDANOSINE IN CEREBROSPINAL-FLUID AND PLASMA DURING INTRACRANIAL SURGERY
CONCENTRATIONS OF ATRACURIUM AND LAUDANOSINE IN CEREBROSPINAL-FLUID AND PLASMA DURING INTRACRANIAL SURGERY
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DOI：
10.1093/bja/63.5.525
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发表时间：
1989-11-01
影响因子：
9.8
通讯作者：
GWINNUTT, CL
中科院分区：
文献类型：
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作者：
EDDLESTON, JM;HARPER, NJN;GWINNUTT, CL
测定了9例颅脑手术患者静脉输注阿曲库铵111~251min维持神经肌肉阻滞时脑脊液和血浆中阿曲库铵和劳丹宁的浓度。阿曲库铵总剂量1.57~2.60 mg·kg~(-1)，血药浓度1.27~5.44微克·毫升~(-1)。脑脊液和血浆中的劳丹宁浓度在输液过程中呈上升趋势，125-140min后分别达到平均值202.5和1448.7 ng/ml。在两份被发现含有阿曲库铵的脑脊液样本中，记录到的最高脑脊液浓度为570ngml-1。手术后，两名患者发作，但这些被认为与鸦片苷无关。结论：阿曲库铵输注过程中，血浆和脑脊液中均有月桂糖苷蓄积。
Concentrations of atracurium and laudanosine in cerebrospinal fluid (CSF) and plasma were assayed in nine patients receiving atracurium infusions of 111-251 min duration to maintain neuromuscular block during intracranial surgery. The total dose of atracurium was 1.57-2.60 mg kg-1 and the plasma concentration of atracurium was 1.27-5.44 .mu.g ml-1. Concentrations of laudanosine in CSF and plasma increased during the infusion period, and after 125-140 min reached means of 202.5 ng ml-1 and 1448.7 ng ml-1, respectively. The highest recorded concentration of laudanosine in CSF was 570 ng ml-1, in one of two CSF samples found to contain atracurium. After operation, two patients had fits, but these were not thought to be related to laudanosine. It is concluded that during infusion of atracurium, laudanosine accumulates in both plasma and CSF.