Testosterone administration to ovariectomized female rhesus monkeys (Macaca mulatta) reduces the frequency of pulsatile luteinizing hormone secretion.
Testosterone administration to ovariectomized female rhesus monkeys (Macaca mulatta) reduces the frequency of pulsatile luteinizing hormone secretion.
复制标题
对切除卵巢的雌性恒河猴（Macaca mulatta）施用睾酮可降低脉动促黄体激素分泌的频率。
DOI：
10.1095/biolreprod32.5.1109
复制
发表时间：
1985
影响因子：
3.6
通讯作者：
Plant,TM
中科院分区：
文献类型：
--
作者：
Dubey,AK;Plant,TM
在雄性恒河猴中，睾酮（T）延缓LH间歇性分泌的频率。本研究的目的是确定T的这种作用是否在女性中是明显的。5只切除卵巢的恒河猴，携带留置心脏导管，皮下植入。一次或多次使用含T的硅橡胶胶囊。在T治疗前每10分钟收集一次血液样本，通常在治疗后1、2、4和8天收集。通过放射免疫法一式两份测量血浆LH浓度，随后用计算机算法进行分析。在卵巢切除猴中，循环T（5-13 ng/ml）的持续增加导致LH脉冲频率从开始T治疗前约每60 min 1次脉冲逐渐降低至此后48 h每100-150 min 1次脉冲。在大多数情况下，脉冲式促性腺激素分泌的减速持续，到T治疗4-8天，观察到LH脉冲频率低至每5小时1次脉冲。T诱导的LH脉冲频率减速的发生通常与LH脉冲幅度的增加和平均LH水平的下降相关。这种LH反应在女性T治疗是类似的，以前报告的男性阉割。
In the male rhesus monkey testosterone (T) retards the frequency of intermittent LH secretion. The purpose of the present study was to determine whether this action of T is demonstrable in the female. Five ovariectomized rhesus monkeys, bearing indwelling cardiac catheters, were implanted s.c. on one or more occasions with T-containing Silastic capsules. Sequential blood samples were collected for 8 h every 10 min before T treatment and usually at 1, 2, 4, and 8 days thereafter. Plasma LH concentrations were measured in duplicate by radioimmunoassay and subsequently analyzed with a computerized algorithm. Sustained increments in circulating T (5–13 ng/ml) in ovariectomized monkeys resulted in a progressive reduction in LH pulse frequencies from approximately 1 pulse every 60 min before initiation of T treatment to 1 pulse every 100–150 min at 48 h thereafter. In most cases the deceleration in pulsatile gonadotropin secretion continued, and by 4–8 days of T treatment LH pulse frequencies as low as 1 pulse every 5 h were observed. The onset of the T-induced deceleration in LH pulse frequency was generally associated with an increase in LH pulse amplitude and with a decline in mean LH levels. This LH response in the female to T treatment was similar to that previously reported for male castrates.