High prevalence of Helicobacter pylori infection in shepherds
High prevalence of Helicobacter pylori infection in shepherds
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DOI：
10.1023/a:1026676223825
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发表时间：
1999-06-01
影响因子：
3.1
通讯作者：
Realdi, G
中科院分区：
文献类型：
--
作者：
Dore, MP;Bilotta, M;Realdi, G
幽门螺杆菌感染地图，在某些情况下，是一种人畜共患病。撒丁岛牧羊人及其家庭与绵羊和牧羊犬接触的幽门螺杆菌感染。撒丁岛牧羊人和献血者对照组完成了关于人口统计学，儿童和当前经济状况以及上消化道相关症状的详细问卷调查。H. pylori状态通过敏感的抗H. pylori IgG和蛋白质印迹法检测抗CagA IgG，A亚组的牧羊犬进行了上消化道内窥镜检查和活检，以评估胃炎的严重程度。H.撒丁岛牧羊人pylori感染率接近100%，与动物接触呈正相关（98%的牧羊人、73%的家庭成员没有定期直接接触动物，而献血者为43%）（P < 0.001）。重要的是，家庭成员与牧羊人分享了相同的童年，但选择了不同的职业（例如，教师、护士、企业），没有经常接触羊。结论：H.撒丁岛牧羊人的幽门螺杆菌感染率是世界上最高的，并且与直接接触绵羊和牧羊犬有关。这些结果表明H.在某些情况下，幽门螺杆菌感染可能包括环境、动物（羊或狗）和人类的各个阶段。
It has been suggested that Helicobacter pylori infection map, in some instances, be a zoonosis, The aim of this study was to evaluate the prevalence of H. pylori infection in Sardinian shepherds and their families in relation to exposure to sheep and sheep dogs. Sardinian shepherds and a control group of blood donors completed detailed questionnaires regarding demographics, childhood and current economic status, and the presence of symptoms related to the upper gastrointestinal tract. H. pylori status was determined by a sensitive ELISA for anti-H. pylori IgG and by western blot for anti-CagA IgG, A subgroup of shepherds had upper gastrointestinal endoscopy with biopsy to assess the severity of the gastritis. H. pylori infection in Sardinian shepherds approached 100% and was positively related to animal contact (98% of shepherds, 73% of family members without regular direct animal contact compared to 43% of blood donors) (P < 0.001). Importantly, the family members shared the same childhood with the shepherds but choose different careers (e.g., teachers, nurses, business) and did not have regular contact with sheep. In conclusion, the prevalence of H. pylori infection in Sardinian shepherds is among the highest in the world and is associated with direct contact with sheep and sheep dogs. These results suggest that the cycle of H. pylori infection might, in certain circumstances, include phases in the environment, animals (sheep or dogs) and human beings.