HUMAN CEREBRAL METABOLISM - STUDIES IN NORMAL SUBJECTS AND PATIENTS WITH DEMENTIA AND AMNESIA
HUMAN CEREBRAL METABOLISM - STUDIES IN NORMAL SUBJECTS AND PATIENTS WITH DEMENTIA AND AMNESIA
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DOI：
10.1111/j.1749-6632.1985.tb37596.x
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发表时间：
1985-01-01
影响因子：
5.2
通讯作者：
MAZZIOTTA, JC
中科院分区：
文献类型：
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作者：
MAZZIOTTA, JC
介绍正电子发射断层扫描（PET）及其在正常和异常记忆功能研究中的应用。PET是测定人类局部脑功能的一种分析性、非侵入性测量工具。通过在正常Ss中使用感觉、运动和神经行为刺激范式，PET已经清楚地证明了脑功能反应的测量。使用PET研究脑疾病患者的病理生理学与仅显示脑结构的成像技术相比，具有许多独特的优势。对痴呆症患者的研究结果表明，痴呆症的严重程度与整个大脑葡萄糖或氧代谢的减少呈正相关。结论是，PET方法提供了以前在人类中无法获得的信息，并有可能评估动物模型在记忆系统研究中的相关性和准确性的局限性。（53 ref）（PsycINFO Database Record (c) 2016 APA，版权所有）
Describes positron emission tomography (PET) and its application to studies of normal and abnormal memory function. PET is an analytic, noninvasive measurement tool for determining local cerebral function in humans. The measurement of functional brain responses with PET has been clearly demonstrated by the use of sensory, motor, and neurobehavioral stimulation paradigms in normal Ss. The study of pathophysiology in patients with cerebral disorders using PET has a number of distinctive advantages over evaluating such patients with imaging techniques that only demonstrate brain structure. Results of studies with dementia patients suggest a positive correlation between the severity of dementia and the reductions in glucose or oxygen metabolism of the brain as a whole. It is concluded that PET methods provide previously unobtainable information in humans and the potential to evaluate the relevancy and limits of accuracy of animal models in the study of memory systems.(53 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)