Gluten ataxia of sporadic and hereditary cerebellar ataxia in patients from mainland China
Gluten ataxia of sporadic and hereditary cerebellar ataxia in patients from mainland China
复制标题
中国大陆患者散发性和遗传性小脑性共济失调的麸质共济失调。
DOI：
10.4103/0028-3886.115056
复制
发表时间：
2013-05-01
期刊：
影响因子：
2.7
通讯作者：
Wang, Jun-Ling
中科院分区：
文献类型：
--
作者：
Guan, Wen-Juan;Liu, Xin-Jian;Wang, Jun-Ling
背景：谷蛋白敏感性（GS）是一种表现多样的疾病谱系。最近的证据表明共济失调可能是GS的唯一表现，它可能是散发性共济失调的原因之一。目的：了解面筋性共济失调在中国患者中的患病率。材料与方法：采用酶联免疫吸附试验（ELISA）检测125例共济失调患者（散发性共济失调100例，遗传性共济失调25例）和51例健康对照者血清抗麦胶蛋白、抗转谷氨酰胺酶2 （TG2）、抗转谷氨酰胺酶6 （TG6）抗体水平。结果：共济失调患者血清抗麦胶蛋白、抗tg2 IgG、IgA、tg6 IgG抗体浓度升高，但升高无统计学意义。散发性共济失调患者血清TG6-IgA水平显著高于健康对照组（P < 0.05）。结论：这些结果提供证据表明，在中国大陆的一个亚组患者中，散发性共济失调可能是由于麸质共济失调引起的。血清抗tg6抗体、抗tg2抗体和抗麦胶蛋白抗体的测定可能有助于诊断麸质共济失调。
Background: Gluten sensitivity (GS) is a spectrum of disorders with diverse manifestations. Recent evidence suggests that ataxia may be the only manifestation of GS and that it may be one of the causes of sporadic ataxia. Aim: To investigate the prevalence of gluten ataxia among patients with ataxia in China. Materials and Methods: Serum levels of anti-gliadin, anti-transglutaminase 2 (TG2), and anti-transglutaminase 6 (TG6) antibodies measured in 125 patients with ataxia (100 patients with sporadic ataxia and 25 patients with hereditary ataxia) and 51 healthy controls by enzyme-linked immunosorbent assay (ELISA). Results: The serum concentrations of anti-gliadin, anti-TG2 IgG, IgA, and TG6-IgG antibodies were elevated in ataxia patients, but the increase was not statistically significant. However, TG6-IgA serum levels were significantly higher in sporadic ataxia as compared to those in healthy controls (P < 0.05). Conclusions: These results provide evidence that sporadic ataxia in a subgroup of patients may be due to gluten ataxia in mainland China. Measurement of serum anti-TG6 antibodies along with anti-TG2 and anti-gliadin antibodies may be useful for diagnosing gluten ataxia.