Improvement in the intestinal absorption of soy protein by enzymatic digestion to oligopeptide in healthy adult men
Improvement in the intestinal absorption of soy protein by enzymatic digestion to oligopeptide in healthy adult men
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DOI：
10.3136/fstr.13.45
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发表时间：
2007-02-01
影响因子：
0.6
通讯作者：
Nakabou, Yukihiro
中科院分区：
文献类型：
--
作者：
Maebuchi, Motohiro;Samoto, Masahiko;Nakabou, Yukihiro
在这项研究中，我们通过测定血清中各种氨基酸浓度的变化，比较了不同来源的肠道吸收相同的氨基酸组成（蛋白质、肽和氨基酸混合物）。本研究中使用的肽是通过酶解I IS球蛋白（大豆蛋白的主要成分）制备的。12名正常男性成年人被要求饮用含有12.5克测试样品的饮料，代表以下三种不同制剂中的5016种悬浊液：11S球蛋白，11S肽和等量成分的氨基酸混合物。0 ~ 180min采集静脉血，测定游离氨基酸浓度。根据血清氨基酸浓度变化计算出的每种氨基酸的血清浓度的早期斜率和曲线下面积值，11S肽明显大于11S球蛋白或氨基酸混合物。这一趋势在支链氨基酸和芳香氨基酸中尤为显著。我们的研究结果表明，在健康成年男性中，摄入水解大豆蛋白比摄入蛋白质或氨基酸混合物更快、更有效地吸收。
In this study, we compared the intestinal absorption from different sources with the same amino acid composition (protein, peptide, and amino acid mixture) by measuring changes in serum concentrations of various amino acids. Peptides used in this study were prepared by enzymatic digestion of I IS globulin (a major component of soy protein). Twelve normal male adults were asked to drink beverages containing 12.5g of the test sample, representing 5016 suspension of each of the following three different preparations: 11S globulin, 11S peptide, and an amino acid mixture of equivalent composition. Venous blood samples were collected from 0 to 180min to measure free amino acid concentrations. The early slope of serum concentrations and values of area under the curves for each amino acid calculated from changes in serum amino acid concentrations were significantly greater for 11S peptide than for either 11S globulin or the amino acid mixture. This trend was especially remarkable for branched-chain amino acids and aromatic amino acids. Our results suggest that the ingestion of hydrolyzed soy protein results in faster and more efficient absorption than the consumption of protein or amino acid mixtures in healthy adult men.