EFFECTS OF D-AMPHETAMINE AND L-AMPHETAMINE ON LOCAL CEREBRAL GLUCOSE-UTILIZATION IN THE CONSCIOUS RAT
EFFECTS OF D-AMPHETAMINE AND L-AMPHETAMINE ON LOCAL CEREBRAL GLUCOSE-UTILIZATION IN THE CONSCIOUS RAT
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DOI：
10.1111/j.1471-4159.1979.tb04504.x
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发表时间：
1979-01-01
影响因子：
4.7
通讯作者：
SOKOLOFF, L
中科院分区：
文献类型：
--
作者：
WECHSLER, LR;SAVAKI, HE;SOKOLOFF, L
安非他明是一种强效的拟交感神经胺，在中枢神经系统中具有强大的兴奋作用。这些作用被认为与安非他明对儿茶酚胺类神经递质的释放和摄取的影响有关。[14 C]脱氧葡萄糖法使研究灰质和白色质不同区域的脑代谢率变化成为可能。由于代谢率和功能活动之间的密切关系，该方法可用于识别大脑中功能活动发生改变的特定结构。用[~（14）C]脱氧葡萄糖法观察了正常清醒大鼠40个灰质结构和4个白色结构中D-和L-苯丙胺（5 mg/kg）代谢率的变化。在锥体外系运动系统的一些组成部分和已知含有多巴胺产生细胞和/或多巴胺感受细胞的一些其他结构中，d-安非他明引起局部脑葡萄糖利用的增加。最大的增加后，d-安非他明管理发生在丘脑底核和网状黑质。左旋苯丙胺使这些相同结构中的一些结构（但不是全部）增加;这些结构一般小于用右旋苯丙胺观察到的结构。d-或l-安非他明给药后，在缰核和下丘脑视交叉上核发现局部脑葡萄糖利用率下降。视交叉上核的这种效应可能反映了它们代谢率的正常昼夜节律。安非他明可能通过影响大脑的特定区域来影响行为。以前只对其中一些区域作为安非他明的可能作用场所进行过研究。
Amphetamine, a potent sympathomimetic amine, has powerful stimulant actions in the CNS. These actions are believed to be related to the influence of amphetamine on release and uptake of catecholamine neurotransmitters. The [14C]deoxyglucose method makes it possible to study changes in cerebral metabolic rate in different areas of gray and white matter. Because of the close relationship between metabolic rate and functional activity, this method may be used to identify specific structures in the brain in which functional activity is altered. The [14C]deoxyglucose method was used to explore for changes in metabolic rate produced by d- and l-amphetamine (5 mg/kg) in 40 gray and 4 white matter structures in normal conscious rats. d-Amphetamine produced increases in local cerebral glucose utilization in a number of components of the extrapyramidal motor system and in some other structures known to contain dopamine-producing and/or dopaminoceptive cells. The largest increases after d-amphetamine administration occurred in the subthalamic nucleus and the zona reticulata of the substantia nigra. l-Amphetamine produced increases in some but not all of these same structures; these were generally smaller than those observed with d-amphetamine. Decreases in local cerebral glucose utilization after either d- or l-amphetamine administration were found in the habenula and the suprachiasmatic nuclei of the hypothalamus. The effects in the suprachiasmatic nuclei may reflect their normal diurnal rhythm in metabolic rate. Amphetamines may influence behavior through effects on specific regions of the brain. Only some of these regions have previously been studied as possible sites of action of amphetamine.