To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient.
To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient.
复制标题
DOI：
10.4331/wjbc.v2.i1.1
复制
发表时间：
2011-01-26
期刊：
影响因子：
--
通讯作者：
Lee MJ
中科院分区：
文献类型：
--
作者：
Liu J;Hsu A;Lee JF;Cramer DE;Lee MJ
大多数造血干细胞（HSPCs）存在于骨髓中，但也有少量造血干细胞通过血液和淋巴在骨髓和组织之间循环。一些证据表明，鞘氨醇-1-磷酸（S1P）梯度触发HSPC从骨髓干细胞壁龛动员后向血液循环的迁移。干细胞也会访问某些组织。HSPCs在局部组织短暂停留36小时后，根据淋巴和组织之间的S1P梯度进入淋巴，最终进入血液循环。S1P在体内还具有引导原始HSPC归巢到BM的作用，因为S1P类似物FTY720处理可以改善HSPC归巢和BM的移植。在应激条件下，各种干细胞或祖细胞可通过调节S1P1、S1P2或S1P3受体的表达水平，被吸引到局部损伤组织，参与局部组织细胞分化和组织重建。因此，S1P对造血干细胞在血液系统中的循环发挥重要作用，完成机体监视和损伤恢复的功能。
Most hematopoietic stem progenitor cells (HSPCs) reside in bone marrow, but a small amount of hematopoietic stem progenitor cells have been found to circulate between bone marrow and tissues through blood and lymph. Several lines of evidence suggest that sphingosine-1-phosphate (S1P) gradient triggers HSPC egression to blood circulation after mobilization from bone marrow stem cell niches. Stem cells also visit certain tissues. After a temporary 36 hours short stay in local tissues, HSPCs go to lymph in response to S1P gradient between lymph and tissue and eventually enter the blood circulation. S1P also has a role in the guidance of the primitive HSPCs homing to BM in vivo, as S1P analogue FTY720 treatment can improve HSPC BM homing and engraftment. In stress conditions, various stem cells or progenitor cells can be attracted to local injured tissues and participate in local tissue cell differentiation and tissue rebuilding through modulation the expression level of S1P1, S1P2 or S1P3 receptors. Hence, S1P is important for stem cells circulation in blood system to accomplish its role in body surveillance and injury recovery.