Significant Polymorphisms of Vitamin D Receptor Gene (rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area
Significant Polymorphisms of Vitamin D Receptor Gene (rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area
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河南农村地区维生素D受体基因(rs2189480和rs3847987)显着多态性与2型糖尿病风险相关
DOI：
10.3967/bes2019.009
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发表时间：
2019
影响因子：
3.5
通讯作者：
Li Wenjie
中科院分区：
文献类型：
--
作者：
Han Han;Zhao Mingxu;Wang Yan;Wang Jun;Ren Bingnan;Ge Huina;Wang Teng;Sun Beibei;Ba Yue;Li Wenjie
2型糖尿病（T2DM）占所有糖尿病病例的90%，并导致严重的并发症。它是一种多因素代谢紊乱疾病，由胰岛素作用抵抗和代偿性胰岛素分泌反应不足共同导致。多种遗传和环境决定因素之间的相互作用被认为与2型糖尿病的发病机制有关[1]。
Type 2 diabetes mellitus (T2DM) accounts for 90% of all diabetes cases and results in severe complications. It is a multifactorial metabolic disorder that results from a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. The interaction between multiple genetic and environmental determinants has been considered to contribute to the pathogenesis of T2DM[1].