Coffee Consumption and Cardiovascular Disease: A Condensed Review of Epidemiological Evidence and Mechanisms
Coffee Consumption and Cardiovascular Disease: A Condensed Review of Epidemiological Evidence and Mechanisms
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DOI：
10.1021/acs.jafc.7b04506
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发表时间：
2018-05-30
影响因子：
6.1
通讯作者：
Lopez-Garcia, Esther
中科院分区：
文献类型：
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作者：
Rodriguez-Artalejo, Fernando;Lopez-Garcia, Esther
咖啡是消费最广泛的饮料之一，一些研究表明它可能与心血管疾病（CVD）有关，心血管疾病是世界上健康状况不佳的主要原因。本综述评估了习惯性咖啡消费对CVD发病率和死亡率影响的证据。该综述主要基于观察性研究和文献的Meta分析。在健康人群中，与不喝咖啡相比，每天习惯性饮用3-5杯咖啡与CVD风险降低15%相关，并且更高的消费量与CVD风险升高无关。此外，与不喝咖啡相比，每天喝1-5杯咖啡与较低的死亡风险有关。在已经患有CVD事件的人中，习惯性消费不会增加CVD复发或死亡的风险。然而，血压不受控制的高血压患者应避免摄入大剂量的咖啡因。对于血压控制良好的人来说，喝咖啡可能是安全的，但这一假设需要进一步的研究来证实。
Coffee is one of the most widely consumed beverages, and some studies have suggested it may be related to cardiovascular disease (CVD), the leading cause of poor health in the world. This review evaluates the evidence on the effect of habitual coffee consumption on CVD incidence and mortality. The review is based mostly on observational studies and meta analyses of the literature. In healthy people, in comparison to not consuming coffee, habitual consumption of 3-5 cups of coffee per day is associated with a 15% reduction in the risk of CVD, and higher consumption has not been linked to elevated CVD risk. Moreover, in comparison to no coffee intake, usual consumption of 1-5 cups/day is associated with a lower risk of death. In people who have already suffered a CVD event, habitual consumption does not increase the risk of a recurrent CVD or death. However, hypertensive patients with uncontrolled blood pressure should avoid consuming large doses of caffeine. In persons with well-controlled blood pressure, coffee consumption is probably safe, but this hypothesis should be confirmed by further investigations.