Chemical methods for degradation of target oligosaccharides using designed light-activatable organic molecules
Chemical methods for degradation of target oligosaccharides using designed light-activatable organic molecules
复制标题
使用设计的光活化有机分子降解目标寡糖的化学方法
DOI：
10.1039/c2cc17384k
复制
发表时间：
2012
影响因子：
4.9
通讯作者：
高橋大介
中科院分区：
文献类型：
--
作者：
Saburo Aimoto*;Ken' ichiro Nakamura;Takeshi Sato;Toru Kawakami;and Toshiaki Hara;高橋大介
碳水化合物在广泛的生物过程中起着至关重要的作用，包括严重的疾病。选择性控制特定寡糖功能的新颖和创新方法的开发在化学、生物学和医学领域引起了广泛关注。在这篇专题文章中，介绍了新型化学工具的发展，这些工具可以在温和的条件下，在没有任何添加剂的情况下，通过特定波长的光照射来降解目标寡糖。这类新型的光化学试剂不仅有望发现分子靶向的生物探针，以了解寡糖的结构-活性关系，而且还有望发现靶向寡糖的新型治疗药物。
Carbohydrates play crucial roles in a wide range of biological processes, including serious diseases. The development of novel and innovative methods for selective control of specific oligosaccharide functions has attracted much attention in the fields of chemistry, biology, and medicine. In this feature article, the development of novel chemical tools, which can degrade target oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, is introduced. This novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure–activity relationships of oligosaccharides but also novel therapeutic drugs targeting oligosaccharides.