Carbohydrate metabolism during exercise: influence of circulating fat availability.
Carbohydrate metabolism during exercise: influence of circulating fat availability.
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运动期间的碳水化合物代谢：循环脂肪可用性的影响。
DOI：
10.1152/jappl.1995.79.2.506
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Wasserman,DH
中科院分区：
文献类型：
--
作者：
Bracy,DP;Zinker,BA;Jacobs,JC;Lacy,DB;Wasserman,DH
为了检查循环脂肪在碳水化合物代谢调节中的作用，在休息和90分钟的中度跑步机运动期间研究了狗，其中输注烟酸以抑制脂肪分解，同时使用（+脂肪; n = 5）或不使用（-脂肪; n = 5）Intraperoid。同位素和后肢动静脉方法用于评估代谢。在休息和运动期间，两种方案中的血糖相似。组间胰岛素、儿茶酚胺和皮质醇的差异不显著。胰高血糖素在休息和运动时高出约50%。以下值代表肌肉工作30或40分钟时的值，因为在这些时间观察到峰值反应。静息时动脉游离脂肪酸水平分别为1，129 +/- 253和272 +/- 17 mu eq/l，运动时+Fat和-Fat分别为756 +/- 145和269 +/- 51 mu eq/l。静息时葡萄糖产量分别为4.2 +/- 0.3和5.0 +/- 0.4 mg.kg-1.min-1，运动时+Fat和-Fat分别为8.5 +/- 1.3和11.4 +/- 0.6 mg.kg-1.min-1。静息时葡萄糖利用率分别为4.3 +/- 0.3和5.3 +/- 0.2 mg.kg-1.min-1，运动时+Fat和-Fat分别为9.2 +/- 1.2和12.7 +/- 0.8 mg.kg-1.min-1。在休息和运动期间存在显著的葡萄糖通量差异。在+脂肪组（29 +/- 7至82 +/- 22 mumol/min）和-脂肪组（28 +/- 7至88 +/- 16 mumol/min）中，肢体葡萄糖摄取量随运动增加相似。动脉血乳酸是50-100%以上，在-脂肪相比，在+脂肪。
To examine the role of circulating fat in the regulation of carbohydrate metabolism, dogs were studied during rest and 90 min of moderate treadmill exercise with nicotinic acid infused to suppress lipolysis with (+Fat; n = 5) or without (-Fat; n = 5) Intralipid. Isotopic and hindlimb arteriovenous methods were used to assess metabolism. Plasma glucose was similar in both protocols during rest and exercise. Differences in insulin, catecholamines, and cortisol between groups were insignificant. Glucagon was approximately 50% greater during rest and exercise in -Fat. The following values represent those at 30 or 40 min of muscular work because peak responses were seen at these times. Arterial free fatty acid levels were 1,129 +/- 253 and 272 +/- 17 mu eq/l at rest and 756 +/- 145 and 269 +/- 51 mu eq/l with exercise in +Fat and -Fat, respectively. Glucose production was 4.2 +/- 0.3 and 5.0 +/- 0.4 mg.kg-1.min-1 at rest and 8.5 +/- 1.3 and 11.4 +/- 0.6 mg.kg-1.min-1 with exercise in +Fat and -Fat, respectively. Glucose utilization was 4.3 +/- 0.3 and 5.3 +/- 0.2 mg.kg-1.min-1 at rest and 9.2 +/- 1.2 and 12.7 +/- 0.8 mg.kg-1.min-1 with exercise in +Fat and -Fat, respectively. Significant glucose flux differences were present during rest and exercise. Limb glucose uptake rose similarly with exercise in +Fat (29 +/- 7 to 82 +/- 22 mumol/min) and -Fat (28 +/- 7 to 88 +/- 16 mumol/min). Arterial blood lactate was 50–100% greater in -Fat compared with that in +Fat.