Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis
Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis
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前后胸廓发育不平衡是脊柱侧弯的致病因素
DOI：
10.1016/j.jot.2018.12.001
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发表时间：
2019-04-01
影响因子：
6.6
通讯作者：
Chen，Lin
中科院分区：
文献类型：
--
作者：
Chen，Bo;Tan，Qiaoyan;Chen，Lin
脊柱侧凸是一种以脊柱弯曲为特征的常见疾病，其严重程度各不相同。关于脊柱侧凸的脊柱变形的生理起源还没有公认的理论。本研究的目的是探讨一个新的假说，表明在脊柱侧凸的曲率可能与胸椎柱和sternum.MethodsWe进行了比较计算机断层扫描（CT）为基础的形态学研究与青少年特发性脊柱侧凸（AIS）和年龄性别匹配的正常人的胸椎和胸骨之间的不平衡增长。我们进一步测量了成纤维细胞生长因子受体3（FGFR 3）缺乏的小鼠的胸骨和胸椎长度之间的比率，这些小鼠表现出脊柱侧凸。采用3周龄C57 BL/6 J小鼠建立双足和胸骨生长板损伤模型。X线片和组织学图像，观察胸骨和脊柱畸形的存在。ResultsThere是一个显着的相关性之间的严重程度脊柱侧凸和胸骨胸椎长度的比率。我们还发现FGFR 3缺陷型小鼠的胸骨与胸椎长度的比值小于野生型小鼠，这与AIS患者相似。手术-胸骨生长板损伤可加速和加重两足小鼠脊柱侧凸的发生，在脊柱侧凸出现之前，胸椎和胸骨的发育不平衡就已经存在。结论胸椎和胸骨的发育不平衡是导致脊柱侧凸包括AIS的重要因素。本文的翻译潜力是：胸椎和胸骨之间的发育不平衡是导致脊柱侧凸的重要因素。胸脊柱和胸骨与脊柱侧凸有关。脊柱侧凸的手术或康复干预应关注与弯曲发病机制有关的所有成分，以获得更好的结果。
ObjectiveScoliosis is a common disease characterized by spinal curvature with variable severities. There is no generally accepted theory about the physical origin of the spinal deformation of scoliosis. The aim of this study was to explore a new hypothesis suggesting that the curvatures in scoliosis may be associated with the imbalance growth between thoracic vertebral column and sternum.MethodsWe undertook a comparative computed tomography (CT) based morphology study of thoracic vertebrae and sternum of patients with adolescent idiopathic scoliosis (AIS) and age-gender matched normal subjects. We further measured the ratios between the lengths of the sternum and thoracic vertebra of mice with deficiency of fibroblast growth factor receptor 3 (FGFR3), which exhibit scoliosis. Three-week-old C57BL/6J mice were used to generate bipedal and sternal growth plate injury model. Radiographs and histological images were obtained to observe the presence of sternal and spinal deformity.ResultsThere was a significant correlation between the severities of scoliosis and the ratios of the sternum to thoracic vertebral lengths. We also found that FGFR3 deficient mice showed smaller ratio of the sternum to thoracic vertebra lengths than that of the wild-type mice, which were similar with that of the AIS patients. Surgery-induced injuries of sternal growth plates can accelerate and aggravate the scoliosis in bipedal mice and imbalanced development of anterior and posterior thoracic occurred before the appearance of scoliosis.ConclusionsOur findings suggest that the imbalanced growth between the thoracic vertebral column and the sternum is an important causative factor for the pathogenesis of scoliosis including AIS.The translational potential of this articleImbalanced growth between the thoracic vertebral column and the sternum is associated with scoliosis. Surgical or rehabilitation intervention for scoliosis should focus on all components involved in the pathogenesis of curvature to obtain better outcome.