Corticotropin (ACTH) induction of tumor necrosis factor alpha by monocytes.
Corticotropin (ACTH) induction of tumor necrosis factor alpha by monocytes.
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DOI：
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发表时间：
1989-10
影响因子：
3.2
通讯作者：
Hughes Tk;Smith Em
中科院分区：
文献类型：
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作者：
Hughes Tk;Smith Em
The finding that monocytes possess specific ACTH receptors led us to determine the effect of ACTH on monokine production. Here, we report that ACTH 1-39 will induce TNF-alpha from the adherent fraction of peripheral blood leukocytes. In addition, we also found that ACTH 1-39 will potentiate IFN-gamma's induction of TNF-alpha from these cells. Since previous reports showed that ACTH inhibits IFN-gamma's activation of macrophages to a cytocidal state, our data raise questions concerning the relative role of TNF-alpha in macrophage mediated cytolysis.
