Heterogeneity of Dengue Illness in Community-Based Prospective Study, Iquitos, Peru
Heterogeneity of Dengue Illness in Community-Based Prospective Study, Iquitos, Peru
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DOI：
10.3201/eid2609.191472
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发表时间：
2020-09-01
影响因子：
11.8
通讯作者：
Paz-Soldan, Valerie A.
中科院分区：
文献类型：
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作者：
Elson, William H.;Reiner, Robert C.;Paz-Soldan, Valerie A.
测量登革热疾病的异质性对于确定登革热疫苗和治疗试验的合适终点至关重要，并将有助于阐明对疾病的行为反应。为了量化登革热疾病（包括较轻病例）的异质性，我们开发了登革热疾病感知反应（IPR）调查，该调查捕获了详细的症状数据，包括强度、持续时间和特征，以及疾病引起的日常活动的变化。 2016-2019 年期间，我们每天收集 79 名登革热病毒 RNA 逆转录 PCR 结果呈阳性的人在疾病急性期的 IPR 数据。大多数参与者患有轻度动态疾病。然而，我们测量了疾病经历、症状持续时间和个体症状的最大报告强度的显着异质性。与单独的症状存在或不存在相比，症状强度是登革热疾病期间主要活动变化更有价值的预测指标。这些数据表明，IPR 可以衡量登革热疾病经历的临床有用异质性及其与人类行为改变的关系。
Measuring heterogeneity of dengue illness is necessary to define suitable endpoints in dengue vaccine and therapeutic trials and will help clarify behavioral responses to illness. To quantify heterogeneity in dengue illness, including milder cases, we developed the Dengue Illness Perceptions Response (IPR) survey, which captured detailed symptom data, including intensity, duration, and character, and change in routine activities caused by illness. During 2016-2019, we collected IPR data daily during the acute phase of illness for 79 persons with a positive reverse transcription PCR result for dengue virus RNA. Most participants had mild ambulatory disease. However, we measured substantial heterogeneity in illness experience, symptom duration, and maximum reported intensity of individual symptoms. Symptom intensity was a more valuable predicter of major activity change during dengue illness than symptom presence or absence alone. These data suggest that the IPR measures clinically useful heterogeneity in dengue illness experience and its relation to altered human behavior.