EFFECT OF ATRIAL NATRIURETIC PEPTIDE ON CORONARY COLLATERAL BLOOD-FLOW
EFFECT OF ATRIAL NATRIURETIC PEPTIDE ON CORONARY COLLATERAL BLOOD-FLOW
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DOI：
10.1161/01.res.65.6.1671
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发表时间：
1989-12-01
影响因子：
20.1
通讯作者：
BACHE, RJ
中科院分区：
文献类型：
--
作者：
FOREMAN, B;DAI, XZ;BACHE, RJ
本研究旨在检查心钠素对冠状动脉侧支血流的影响。在对左冠状动脉前降支进行栓塞闭塞以刺激侧支血管生长后 3.4 个月，对 9 只成年杂种狗进行了研究。在研究时，对冠状动脉前降支进行插管，以便通过测量逆行血流来估计动脉间侧支流量。在逆行血流收集过程中注射放射性微球可以同时测定连续的组织血流，以评估微血管侧支交通。向左心房施用剂量为20和200μg的心房钠尿肽导致17.+-。 3.0% 和 34.+-。逆流分别增加 4.5%（每个 p < 0.01）。侧支依赖性心肌区域中的组织流量不响应心房钠尿肽、硝酸甘油肽的施用而改变，硝酸甘油的施用(10μg/kg进入左心房)没有引起逆行血流量的进一步增加，并且侧支血管阻力没有进一步降低。这些数据表明心房肽引起中等发育良好的动脉间冠状侧支血管的血管舒张。
This study was carried out to examine the effects of atrial natriuretic peptide on coronary collateral blood flow. Studies were performed in nine adult mongrel dogs 3.4 months after embolic occlusion of the left anterior descending coronary artery had been perforemed to stimulate collateral vessel growth. At the time of study the anterior descending coronary artery was cannulated to allow estimation of interarterial collateral flow from measurements of retrograde blood flow. Injection of radioactive microspheres during retrograde flow collection allowed simultaneous determination of continuing tissue flow for evaluation of microvascular collateral communications. Atrial natriuretic peptide in doses of 20 and 200 .mu.g administered into the left atrium resulted in 17 .+-. 3.0% and 34 .+-. 4.5% increases in retrograde flow, respectively (each p < 0.01). Tissue flow in the collateral dependent myocardial region did not change in response to atrial natriuretic peptide, the administration of nitroglycerin peptide, the administration of nitroglycerin (10 .mu.g/kg into the left atrium) caused no further increase of retrograde blood flow, and no further decrease of collateral vascular resistance. These data indicate that atrial peptide causes vasodilation of moderately well-developed interarterial coronary collateral vessels.