Immunomodulation of murine leishmaniasis with cyclosporin A.
Immunomodulation of murine leishmaniasis with cyclosporin A.
复制标题
用环孢菌素 A 对小鼠利什曼病进行免疫调节。
DOI：
10.1007/978-1-4757-5421-6_36
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发表时间：
1988
影响因子：
--
通讯作者：
Wenger,CD
中科院分区：
文献类型：
--
作者：
Behforouz,NC;Wenger,CD
真菌代谢产物环孢素A （cyclosporin A, CsA）是一种非肽，具有新的免疫抑制作用以及抗寄生虫和抗炎特性（1,2）。在体外和体内T细胞反应的诱导阶段，CsA在防止T辅助细胞和T细胞毒性细胞的激活方面特别有效(3)。虽然CsA的作用方式尚不完全清楚，但它已被证明可以抑制IL-2的产生，并可能对其他淋巴细胞的通讯信号和反应性产生影响（2-4）。在人类疾病的动物模型中，环孢素A已被证明对某些寄生虫感染具有意想不到的有益作用。在小鼠疟疾中，环孢素A对stp表现出有效的活性。yoeliiandP。Bergheiwhen给予小鼠预防或治疗（5,6）。此外，CsA还能显著抑制恶性疟原虫培养的人红细胞的生长(6)。在这项工作中，该药物的治疗和预防作用被认为是由于CsA对疟原虫的直接作用。令人惊讶的是，CsA对感染了曼氏血吸虫的小鼠也有保护作用。动物受到保护，免受原发感染和继发感染（7,8）。然而，在这些研究中，没有观察到药物对寄生虫的直接作用，结论是药物引起了针对寄生虫的宿主机制的刺激(8)。与这些研究相反，发现CsA治疗克氏锥虫感染小鼠会加重该疾病(9)。
The fungal metabolite, cyclosporin A (CsA), is an undecapeptide with novel immunosuppressive effects as well as anti-parasitic and antiinflammatory properties (1,2). CsA is particularly effective in preventing activation of T helper and T cytotoxic cells at the induction phase of T cell responses bothin vitroandin vivo(3). Although the mode of action of CsA is not yet entirely clear, it has been shown to inhibit the production of IL-2 and may have effects on other lymphoid communication signals and responsiveness (2–4). Cyclosporin A has been shown to have unexpected beneficial effects on certain parasitic infections in animal models of human disease. In murine malaria, cyclosporin A exhibited potent activity againstP. yoeliiandP. bergheiwhen administered to mice either prophylactically or therapeutically (5,6). Furthermore, CsA also markedly inhibited the growth ofPlasmodium falciparumin cultured human erythrocytes (6). In this work, both the therapeutic and prophylactic effects of the drug were thought to be due to the direct effect of the CsA on thePlasmodiumparasites. Surprisingly, CsA also had protective effects in mice infected with the helminthSchistosoma mansoni. Animals were protected both from primary infections and secondary challenges (7,8). In these studies, however, no direct effect of the drug on the parasite was observed, and it was concluded that the drug evoked a stimulation of host mechanisms directed against the parasite (8). In contrast to these studies, CsA treatment ofTrypanosoma cruziinfected mice was found to exacerbate the disease (9).