Effect of oral D-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats
Effect of oral D-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats
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DOI：
10.1016/j.fertnstert.2007.01.109
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发表时间：
2007-10-01
影响因子：
6.7
通讯作者：
Jalaeian, Hamed
中科院分区：
文献类型：
--
作者：
Nikeghbalian, Saman;Atefi, Sohrab;Jalaeian, Hamed
目的：评价（D）-青霉胺预防或减少粘连带形成的作用，并与秋水仙碱在动物模型中的作用进行比较。设计：前瞻性实验研究。设置：大鼠在学术研究环境。动物（S）：将80只雌性大鼠随机分为4组。最后，第4组因死亡率高而被排除在外。干预（S）：通过腹膜内注射2.5 mL 10%无菌滑石粉溶液诱导粘连带。第1组为对照组，第2组口服D-青霉胺（35 mg/kg/d），第3组口服秋水仙碱（0.02 mg/kg/d），第4组同时口服两种药物，连续3周。主要观察指标：根据Nair分类对粘连带的形成进行定量分级。结果：具有大量粘连带的对照组大鼠比例显著高于第2组或第3组大鼠（84.2%、20%和33.3%）。D-青霉胺和秋水仙碱组之间的粘连带等级无差异。结论：口服D-青霉胺与口服秋水仙碱预防大鼠腹腔粘连带形成的效果相同。为此目的使用D-青霉胺应权衡其可能的副作用。（Fertil Steril（R）2007;88（增刊2）：1187-9.（C）2007年由美国生殖医学协会。
Objective: To evaluate the effects Of (D)-penicillamine on prevention or reduction of adhesion band formation and to compare its effects with those of colchicine in an animal model. Design: A prospective experimental study. Setting: Rats in an academic research environment. Animal(S): Eighty female rats were randomly divided into four equal groups. In the end, group 4 was excluded because of high mortality rates. Intervention(S): Adhesion bands were induced by intraperitoneal, injection of 2.5 mL of a 10% sterile talc solution. The first group served as control, group 2 received oral D-penicillamine (35 mg/kg per day), group 3 received oral colchicines (0.02 mg/kg per day), and group 4 received both drugs for 3 consecutive weeks. Main Outcome Measure(s): Formation of adhesion bands was quantitatively graded according to the Nair classification. Result(s): The proportion of control rats with substantial adhesion bands was significantly higher than that of rats in groups 2 or 3 (84.2%, 20%, and 33.3%). No difference regarding the grades of adhesion bands was found between the D-penicillamine and colchicine groups. Conclusion(s): Oral D-penicillamine is as effective as oral colchicine in prevention of peritoneal adhesion band formation in rats. Use Of D-penicillamine for this purpose should be weighed against its possible side effects. (Fertil Steril (R) 2007;88(Suppl 2):1187-9. (C)2007 by American Society for Reproductive Medicine.)