Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer
Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer
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DOI：
10.21873/anticanres.11511
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发表时间：
2017-04-01
影响因子：
2
通讯作者：
Lee, Won-Suk
中科院分区：
文献类型：
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作者：
Jang, Ho Hee;Lee, Hae Na;Lee, Won-Suk
背景：最近的研究表明 RNA 结合蛋白 (RBP) 在包括癌症进展在内的多种生物途径中具有潜在作用，而它们在各种肿瘤类型中的表达可能与患者预后相关。然而，RBP 家族成员在结肠癌中的作用尚未被探索，并且它们作为预后生物标志物的可能性很大程度上未知。材料和方法：为了确定结肠癌中三个 RBP 基因的预后作用：胰岛素样生长因子结合蛋白 2 (IGFBP2)、RNA 结合基序蛋白 3 (RBM3) 和冷诱导 RNA 结合蛋白 (CIRP)。结果：我们使用定量实时聚合酶链反应 (qRT-PCR) 检查了 94 份人类结肠癌样本以及每位患者的匹配正常组织样本中 IGFBP2、RBM3 和 CIRP 的 RNA 表达。 RBPs 的 RNA 表达与所研究的临床特征之间没有观察到显着关联。 RBM3和CIRP表达较高的患者的估计5年无病生存率明显更高，而患者生存率与IGFBP2表达不显着相关。结论：RBM3 和 CIRP 可能是结肠癌有用的预后生物标志物。
Background: Recent studies have shown a potential role of RNA-binding proteins (RBPs) in a variety of biological pathways, including cancer progression, whilst their expression in various tumor types may be associated with patient prognosis. However, the role of the RBP family members has not been explored in colon cancer and their possible use as prognostic biomarkers is largely unknown. Materials and Methods: To determine the prognostic role of three RBP genes: insulin-like growth factor-binding protein 2 (IGFBP2), RNA-binding motif protein 3 (RBM3), and cold-inducible RNA-binding protein (CIRP) in colon cancer. Results: We examined the RNA expression of IGFBP2, RBM3, and CIRP in 94 human colon cancer samples along with matched normal tissue samples from each patient using quantitative real-time polymerase chain reaction (qRT-PCR). No significant associations were observed between RNA expression of RBPs and the studied clinical features. The estimated 5-year disease-free survival rate was significantly better for patients with higher expression of RBM3 and CIRP, while patient survival was not significantly correlated to IGFBP2 expression. Conclusion: RBM3 and CIRP may be useful prognostic biomarkers of colon cancer.