Short-term functional plasticity in the human auditory cortex:: an fMRI study
Short-term functional plasticity in the human auditory cortex:: an fMRI study
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DOI：
10.1016/s0926-6410(01)00092-1
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发表时间：
2001-12-01
期刊：
影响因子：
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通讯作者：
Heinze, HJ
中科院分区：
文献类型：
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作者：
Jäncke, L;Gaab, N;Heinze, HJ
应用功能磁共振成像 (fMRI) 技术，在受试者使用奇怪程序进行五次频率辨别训练（超过 1 周）之前和之后 1 周，测量由 950 Hz（标准）纯音和 952、954 和 958 Hz 异常音调序列引起的血流动力学反应。受试者的任务是检测与标准刺激不同的异常现象。训练期间，三个科目的频率辨别力有所改善（成绩提升：T+），但其他三个科目则没有改善（无成绩提升：T-）。仅在 T+ 组的训练期间，听觉皮层（包括颞平面、极平面和颞上沟）的血流动力学反应显着下降。这些激活变化对于那些伴随最强性能增益（958 和 954 Hz）的刺激来说是最强的。 T组和未接受任何音调辨别训练的对照组（CO）的听觉皮层的血流动力学反应没有差异。结果表明，训练频率的皮质表征进行了可塑性重组，这可以根据“快速学习”理论得到最好的解释。 (C) 2001 Elsevier Science BY 保留所有权利。
Applying functional magnetic resonance imaging (fMRI) techniques, hemodynamic responses elicited by sequences of pure tones of 950 Hz (standard) and deviant tones of 952, 954, and 958 Hz were measured before and I week after subjects had been trained at frequency discrimination for five sessions (over 1 week) using an oddball procedure. The task of the subject was to detect deviants differing from the standard stimulus. Frequency discrimination improved during the training session for three subjects (performance gain: T+) but not for three other subjects (no performance gain: T-). Hemodynamic responses in the auditory cortex comprising the planum temporale, planum polare and sulcus temporalis superior significantly decreased during training only for the T+ group. These activation changes were strongest for those stimuli accompanied by the strongest performance gain (958 and 954 Hz). There was no difference with respect to the hemodynamic responses in the auditory cortex for the T- group and the control group (CO) who did not received any pitch discrimination training. The results suggest a plastic reorganization of the cortical representation for the trained frequencies which can be best explained on the basis of 'fast learning' theories. (C) 2001 Elsevier Science BY All rights reserved.