LIPOPOLYSACCHARIDE TOXICITY-REGULATING PROTEINS IN BACTEREMIA
LIPOPOLYSACCHARIDE TOXICITY-REGULATING PROTEINS IN BACTEREMIA
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DOI：
10.1093/infdis/171.5.1250
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发表时间：
1995-05-01
影响因子：
6.4
通讯作者：
BUURMAN, WA
中科院分区：
文献类型：
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作者：
FROON, AHM;DENTENER, MA;BUURMAN, WA
脂多糖（LPS）的毒性被几种蛋白质修饰，例如杀菌/通透性增加蛋白（BPI）和LPS结合蛋白（LBP）。在革兰氏阴性菌血症（n = 36）或革兰氏阳性菌血症（n = 28）患者中测定BPI和LBP血浆水平。BPI和LBP的水平在首次检测到菌血症之前增加，它们分别是中和和增强LPS作用的蛋白质。反映中性粒细胞活化的BPI/中性粒细胞比率与菌血症患者中脓毒症综合征和死亡的存在显著相关：1.06（0.11-6.49）与0.57（0.06-3.82）在有和无脓毒症综合征的患者中（P <0.01），存活者和非存活者分别为0.64（0.06-3.82）和1.02（0.12-6.49）（P <0.05）（每10（6）个中性粒细胞中BPI的纳克数比）。高LBP峰值水平与脓毒症综合征的存在显著相关（P <0.01）。在革兰氏阴性菌血症与革兰氏阳性菌血症患者中，未观察到BPI和LBP水平的差异。BPI/中性粒细胞比率作为中性粒细胞活化的参数，可能有助于监测传染病。
The toxicity of lipopolysaccharide (LPS) is modified by several proteins, such as bactericidal/permeability-increasing protein (BPI) and LPS-binding protein (LBP). BPI and LBP plasma levels were measured in patients with gram-negative (n = 36) or gram-positive (n = 28) bacteremia. Levels of BPI and LBP, which are proteins that neutralize and enhance LPS effects, respectively, were increased before bacteremia was first detected. The BPI/neutrophil ratio, reflecting neutrophil activation, was significantly associated with the presence of sepsis syndrome and death in bacteremic patients: 1.06 (0.11-6.49) versus 0.57 (0.06-3.82) in patients with and without sepsis syndrome (P < .01), respectively, and 0.64 (0.06-3.82) versus 1.02 (0.12-6.49) in survivors and nonsurvivors (P < .05), respectively (ratio in nanograms of BPI per 10(6) neutrophils). High LBP peak levels were significantly associated with the presence of sepsis syndrome (P < .01). No differences in BPI and LBP levels were observed in patients with gram-negative versus gram-positive bacteremia. BPI/neutrophil ratio, as a parameter of neutrophil activation, may be useful in monitoring infectious disease.