Correlation of Fundus Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography in Identification of Membrane Subtypes in Neovascular Age-Related Macular Degeneration
Correlation of Fundus Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography in Identification of Membrane Subtypes in Neovascular Age-Related Macular Degeneration
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DOI：
10.1159/000355091
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发表时间：
2014-01-01
期刊：
影响因子：
2.6
通讯作者：
Sivaprasad, Sobha
中科院分区：
文献类型：
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作者：
Mathew, Raeba;Pefkianaki, Maria;Sivaprasad, Sobha
目的：评估与荧光素眼底血管造影术（FFA）相比，光谱域光学相干断层扫描（SDOCT）确定新生血管性年龄相关性黄斑变性（AMD）脉络膜新生血管（CNV）亚型的灵敏度和特异性，以及两种程序之间的一致性。设计：这是一项回顾性、观察性研究。方法：我们评估并比较了100只接受雷珠单抗治疗的新生血管性AMD患者的FFA和OCT CNV亚型。结果：SDOCT对CNV亚型诊断的敏感性（85.7-98.3%）和特异性（84.2 ~ 100%）均高于FFA。不同CNV亚型的受试者操作特征曲线下面积范围为0.9至0.93（p值< 0.0001）。加权kappa统计显示，程序之间的一致性接近0.85。结论：SDOCT是诊断新生血管性AMD CNV亚型的可靠工具，无需FFA等侵入性检查。(C)2013 S. Karger AG，巴塞尔
Aims: To assess the sensitivity and specificity of spectral-domain optical coherence tomography (SDOCT) for the determination of choroidal neovascularization (CNV) subtypes in neovascular age-related macular degeneration (AMD) compared to fundus fluorescein angiography (FFA) and also the agreement between the two procedures. Design: This was a retrospective, observational study. Methods: We evaluated and compared the CNV subtypes on FFA and OCT in 100 eyes initiated on ranibizumab for neovascular AMD. Results: SDOCT showed high sensitivity (85.7-98.3%) and specificity (84.2-100%) compared to FFA in the diagnosis of the CNV subtype. The area under the receiver-operating characteristic curve ranged from 0.9 to 0.93 (p value < 0.0001) for the different CNV subtypes. Weighted kappa statistics showed a near-perfect agreement of 0.85 between the procedures. Conclusion: SDOCT is a reliable tool for the diagnosis of CNV subtypes in neovascular AMD obviating the need for an invasive procedure such as FFA. (C) 2013 S. Karger AG, Basel