Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction
Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction
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DOI：
10.1101/lm.1474609
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发表时间：
2009-09-01
影响因子：
2
通讯作者：
Westbrook, R. Frederick
中科院分区：
文献类型：
--
作者：
Laurent, Vincent;Westbrook, R. Frederick
大鼠进行一个或两个周期的上下文恐惧条件化和消退，以研究前边缘皮层（PL）和边缘下皮层（IL）在学习和再学习中的作用，以抑制恐惧反应。失活的PL抑郁的恐惧反应在第一次或第二次灭绝，但不损害学习或再学习恐惧抑制（实验1）。IL的失活不影响第一次消退的抑制，但破坏了其长期保留。IL的失活损害了第二次消退的抑制，并且在该消退之前或之后的失活损害了长期保留（实验2和3）。在保留测试之前IL的失活恢复了被消除的恐惧反应（实验4）。这些结果首次表明，PL的神经元活动参与恐惧反应的表达，但不参与长期恐惧抑制的基础学习。他们还证实了IL参与了这种抑制性学习：具体来说，他们表明IL对这种抑制性学习的巩固和恢复至关重要。IL的作用进行了讨论的当代神经模型的恐惧灭绝。
Rats were subjected to one or two cycles of context fear conditioning and extinction to study the roles of the prelimbic cortex (PL) and infralimbic cortex (IL) in learning and relearning to inhibit fear responses. Inactivation of the PL depressed fear responses across the first or second extinction but did not impair learning or relearning fear inhibition (experiment 1). Inactivation of the IL did not affect inhibition across the first extinction but disrupted its long-term retention. Inactivation of the IL impaired inhibition across the second extinction, and inactivation before or after this extinction impaired long-term retention (experiments 2 and 3). Inactivation of the IL before the retention test restored extinguished fear responses (experiment 4). These results show for the first time that neuronal activity in the PL is involved in the expression of fear responses but not in the learning that underlies long-term fear inhibition. They also confirm that the IL is involved in this inhibitory learning: Specifically, they show that the IL is critical for consolidation and retrieval of this inhibitory learning. The role of the IL is discussed in terms of a contemporary neural model of fear extinction.