Physiological Functions of APP Family Proteins
Physiological Functions of APP Family Proteins
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DOI：
10.1101/cshperspect.a006288
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发表时间：
2012-02-01
影响因子：
5.4
通讯作者：
Zheng, Hui
中科院分区：
文献类型：
--
作者：
Mueller, Ulrike C.;Zheng, Hui
生化和遗传证据表明淀粉样蛋白前体蛋白（APP）在阿尔茨海默病（AD）发病机制中的核心作用。从生物化学角度来看，APP蛋白水解过程中产生的β -淀粉样蛋白（A β）肽的沉积是AD的决定性病理标志；从遗传学上讲，野生型APP的点突变和重复都与家族性AD （FAD）和脑淀粉样血管病的一个亚群有关。因此，APP及其加工产品的生物学功能一直是人们研究的热点，过去20多年的研究既令人兴奋又充满挑战。本文将从APP家族成员的角度对APP的生理功能进行综述。
Biochemical and genetic evidence establishes a central role of the amyloid precursor protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the beta-amyloid (A beta) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically, both point mutations and duplications of wild-type APP are linked to a subset of early onset of familial AD (FAD) and cerebral amyloid angiopathy. As such, the biological functions of APP and its processing products have been the subject of intense investigation, and the past 20+ years of research have met with both excitement and challenges. This article will review the current understanding of the physiological functions of APP in the context of APP family members.