On the neuromodulatory pathways of the in vivo brain by means of transcranial focused ultrasound
On the neuromodulatory pathways of the in vivo brain by means of transcranial focused ultrasound
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DOI：
10.1016/j.cobme.2018.10.004
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发表时间：
2018-12-01
影响因子：
3.9
通讯作者：
He, Bin
中科院分区：
文献类型：
--
作者：
Niu, Xiaodan;Yu, Kai;He, Bin
近十年来，低强度经颅聚焦超声（tFUS）在神经调节方面得到了迅速发展，取得了无数成功的应用。作为一种无创神经调节工具，tFUS具有高空间分辨率、聚焦性和深度穿透性。尽管前景看好，但在啮齿类动物中，当刺激参数选择不仔细时，可以观察到混杂激活。在这里，我们总结了超声神经调节的两类现有观察：超声直接激活局部区域，或超声间接激活听觉通路，并进一步传播到其他皮层网络。我们也提出了体内动物对照研究，表明潜在的tFUS脑调节的特点是独立于听觉网络激活的局部反应。
For last decade, low-intensity transcranial focused ultrasound (tFUS) has been rapidly developed for a myriad of successful applications in neuromodulation. tFUS possesses high spatial resolution, focality and depth penetration as a noninvasive neuromodulation tool. Despite the promise, confounding activation can be observed in rodents when stimulation parameters are not selected carefully. Here we summarize the two existing classes of observations for ultrasound neuromodulation: ultrasound directly activates a localized area, or ultrasound indirectly activates auditory pathways, which further propagates to other cortical networks. We also present in vivo animal control studies, which suggest that underlying tFUS brain modulation is characterized by localized response independent of auditory networks activations.