Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity
Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity
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DOI：
10.1161/hypertensionaha.107.101824
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发表时间：
2008-02-01
期刊：
影响因子：
8.3
通讯作者：
Gutterman, David D.
中科院分区：
文献类型：
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作者：
Phillips, Shane A.;Jurva, Jason W.;Gutterman, David D.
肥胖与内皮依赖性血流介导的扩张受损有关，这是高血压和动脉粥样硬化的前兆。虽然节食通常可以改善心血管危险因素，但不同饮食策略对血管内皮功能的直接影响尚不清楚。本研究的目的是验证低脂（LF）饮食与等热量低碳水化合物（LC）饮食相比可以改善内皮功能的假设。肥胖（n=20；体重指数：29至39；平均收缩压：107至125毫米汞柱）和其他健康的志愿者被随机分配到美国心脏协会模型LF（30%脂肪卡路里）饮食或等热量LC阿特金斯风格饮食（20克碳水化合物）6周（4周体重减轻和2周维持阶段）。采用超声自动边缘检测技术（基线、第2周和第6周）测量肱血流介导的舒张和对硝酸甘油的舒张。在整个研究过程中测量了血压、体重减轻和胆固醇水平。LF组体重减轻相似（100+/-4 ~ 96.1+/-4 kg）
Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis. Although dieting generally improves cardiovascular risk factors, the direct effect of different dietary strategies on vascular endothelial function is not known. The purpose of this study was to test the hypothesis that a low-fat (LF) diet improves endothelial function compared with an isocaloric low-carbohydrate (LC) diet. Obese (n=20; body mass index: 29 to 39; mean systolic blood pressure: 107 to 125 mm Hg) and otherwise healthy volunteers were randomly assigned to either the American Heart Association modeled LF (30% fat calories) diet or an isocaloric LC Atkins' style diet (20 g of carbohydrates) for 6 weeks (4-week weight loss and 2-week maintenance phase). Brachial flow-mediated dilation and dilation to nitroglycerin were measured with ultrasound using automated edge detection technology (baseline, week 2, and week 6). Blood pressure, weight loss, and cholesterol profiles were measured throughout the study. Weight loss was similar in LF (100+/-4 to 96.1+/-4 kg; P